Daily Multiple Formula Vitamin/Mineral/Antioxidant
Pre-Conception Vitamins for Women and Men
Now with 800IU Vitamin D!
An optimal potency multiple vitamin/mineral/trace mineral formula performs at least three important roles in pre-conception and fertility enhancement:
I.) Supplies high potency (meaningful dose) antioxidant nutrientsincluding vitamins C and E, beta carotene, zinc, selenium, copper and manganese. Excess Radical Oxygen Species (ROS) are detrimental to both natural and assisted fertility1-5 and play a role in infertility in conditions such as polycystic ovarian disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole, embryopathies, preterm labor, and intrauterine growth retardation.4-5
II.) Increases rate of conception. Multiple vitamin supplementation during the pre-conception has been shown to increase rate of conception and decrease time to conception,6-7,51 important because nutritional deficiencies are common even in industrialized countries.8
III.) Decreases congenital abnormalities. Pre-conception multivitamin supplementation has been shown to decrease congenital abnormalities including neural tube defects, cardiovascular defects, limb defects, congenital hydrocephalus, urinary tract anomalies and cleft palate.9-13 Multiple vitamins containing folic acid are more effective than high dose folic acid alone for preventing birth defects.10-13
An optimal potency multiple has been shown to increase fertility in both men and women.1-13,51 In addition, there are specific nutrients known to be important to men and women in varying amounts to improve fertility, pregnancy and healthy baby outcomes.
How Does Your “Multiple” or “Pre-Natal” Compare?
Most multiple vitamin-mineral formulas, even those called “pre-natal,” are low potency formulas that do not contain the higher doses of critical nutrients shown to improve fertility.
For the purpose of pre-conception fertility enhancement, the following nutrient dose ranges are recommended for men and women based on the medical literature:
|Ingredient||Benefit (Refs)||Optimal Dose Range Female||Benefit
|Optimal Dose Range Male||Maxi Multi Contains|
|“Multiple” formula||1-13, 51||indet.*||indet.*|
C and E below
|see vit. C,E, selenium & zinc below||YES -Optimal Potency|
|B Complex||51,52,58||indet.*||52||indet.*||Yes-see label below|
|Carotenes||23||indet.*||Yes- see label below|
|100-1,000 IU||400 IU|
|Vitamin D||55||600-1,000 IU||55||600-1,000 IU||800 IU|
|Vitamin B12 (as methylcobalamine)||45,46||400 – 1,000 mcg||41-47||400-6000 mcg||400 mcg|
|Selenium||50-200 mcg||28-29,57||200-225 mcg||200 mcg|
|Zinc||56||15-25mg||30-40,57||15-66 mg||20 mg|
|indet = “Indeterminate.” The nutrient is known to be essential for pre-conception but the optimal dose is not clear from the medical literature.|
Why Pre-Natal Vitamins are NOT Recommended for Pre-Conception Supplementation
- Prenatal formulas do not contain the above-listed target doses
of fertility-enhancing nutrients.
- Prenatal formulas contain high doses of iron. Excess iron impairs fertility and should onlybe supplemented when specifically recommended by your doctor based on blood testing.
Why Dr. Braverman Recommends Maxi Multi
Maxi Multi is a state-of-the-art formulation of vitamins, minerals, antioxidants and bioflavonoids with highly concentrated plant enzymes for optimal assimilation.
Maxi Multi contains optimal, not minimal, doses of nutrients necessary for overall good health. In addition,
Maxi Multi contains target doses of the nutrients known to promote fertility in both men and women. Very few supplement formulas contain these “target levels” of nutrients.
Maxi Multi is an Optimal Potency multiple vitamin and mineral formula. that typically replaces at least five separate formulas:
- High potency multiple vitamin /mineral / trace mineral supplement
- High potency multiple B-complex vitamins
- High potency antioxidants (A, carotenes, C, E, selenium, zinc)
- High potency calcium / magnesium (1,000:400) plus other bone-building nutrients (boron, vitamin D)
If you only take one pre-conception supplement, this should be THE ONE!
The addition of Plant Enzymes ensures absorption of nutrients. This formula is hypoallergenic, ultra pure and suitable for even highly sensitive individuals.
Suggested dose – 9 Capsules per day, in divided doses with meals.
Provides target nutrient doses for both men and women.
Product # 160 (270 Caps – a 30 day supply) $39.95
Nine (9) Capsules contain:
1.) Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in female infertility – a clinician’s perspective. Reprod Biomed Online. 2005 Nov;11(5):641-50.
2.) Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol. 2006 Jun;18(3):325-32.
3.) Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003 Apr;79(4):829-43.
4.) Agarwal A, Allamaneni SS. Role of free radicals in female reproductive diseases and assisted reproduction. Reprod Biomed Online. 2004 Sep;9(3):338-47.
5.) Agarwal A, Gupta S, Sekhon L, Shah R. Redox considerations in female reproductive function and assisted reproduction: from molecular mechanisms to health implications. Antioxid Redox Signal. 2008 Aug;10(8):1375-403.
6.). Czeizel AE, Metneki J, Dudas I. The effect of preconceptional multivitamin supplementation on fertility. Int J Vitam Nutr Res. 1996;66(1):55-8.
7.) Czeizel AE. Periconceptional folic acid containing multivitamin supplementation. Eur J Obstet Gynecol Reprod Biol. 1998 Jun;78(2):151-61.
8.) ESHRE Capri Workshop Group. Nutrition and reproduction in women. Hum Reprod Update. 2006 May-Jun;12(3):193-207. Epub 2006 Jan 31.
9.) Wilson RD, Johnson JA, Wyatt P, Allen V, Gagnon A, Langlois S, Blight C, Audibert F, Désilets V, Brock JA, Koren G, Goh YI, Nguyen P, Kapur B; Genetics Committee of the Society of Obstetricians and Gynaecologists of Canada and The Motherrisk Program. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. J Obstet Gynaecol Can. 2007 Dec;29(12):1003-26.
10.) Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis.J Obstet Gynaecol Can. 2006 Aug;28(8):680-9.
11.) Czeizel AE, Dobó M, Vargha P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Res A Clin Mol Teratol. 2004 Nov;70(11):853-61.
12.) Goh YI, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis.J Obstet Gynaecol Can. 2006 Aug;28(8):680-9.
13.) Czeizel AE. The primary prevention of birth defects: Multivitamins or folic acid? Int J Med Sci. 2004;1(1):50-61. Epub 2004 Mar 20.
14.) Wang L, Huang P, Huang X. [Analysis on the treatment of 1,020 patients with immunologic infertility] Zhonghua Fu Chan Ke Za Zhi. 1999 Apr;34(4):234-6.
15.) Luck MR, Jeyaseelan I, Scholes RA. Ascorbic acid and fertility. Biol Reprod. 1995 Feb;52(2):262-6.
16. Fraga CG, Motchnik PA, Shigenaga MK, et al. Ascorbic acid protects against endogenous oxidative DNA damage in human sperm. Proc Natl Acad Sci 1991;88:11003–6.
17. Dawson EB, Harris WA, Teter MC, Powell LC. Effect of ascorbic acid supplementation on the sperm quality of smokers. Fertil Steril 1992;58:1034–9.
18. Dawson EB, Harris WA, McGanity WJ. Effect of ascorbic acid on sperm fertility. Fed Proc 1983;42:531 [abstr 31403].
19. Dawson EB, Harris WA, Powell LC. Relationship between ascorbic acid and male fertility. In: Aspects of Some Vitamins, Minerals and Enzymes in Health and Disease, ed. GH Bourne. World Rev Nutr Diet 1990;62:1–26 [review].
20. Dawson EB, Harris WA, Rankin WE, et al. Effect of ascorbic acid on male fertility. Ann N Y Acad Sci 1987;498:312–23.
21. Greco E, Romano S, Iacobelli M, Ferrero S, Baroni E, Minasi MG, Ubaldi F, Rienzi L, Tesarik J. ICSI in cases of sperm DNA damage: beneficial effect of oral antioxidant treatment. Hum Reprod. 2005 Sep;20(9):2590-4. Epub 2005 Jun 2.
22.Greco E, Iacobelli M, Rienzi L, Ubaldi F, Ferrero S, Tesarik J. Reduction of the incidence of sperm DNA fragmentation by oral antioxidant treatment. J Androl. 2005 May-Jun;26(3):349-53.
23.Eskenazi B, Kidd SA, Marks AR, Sloter E, Block G, Wyrobek AJ. Antioxidant intake is associated with semen quality in healthy men. Hum Reprod. 2005 Apr;20(4):1006-12. Epub 2005 Jan 21.
24.Crha I, Hrubá D, Ventruba P, Fiala J, Totusek J, Visnová H. Ascorbic acid and infertility treatment. Cent Eur J Public Health. 2003 Jun;11(2):63-7.
25.Bayer R. Treatment of infertility with vitamin E. Int J Fertil 1960;5:70–8.
26. Geva E, Bartoov B, Zabludovsky N, et al. The effect of antioxidant treatment on human spermatozoa and fertilization rate in an in vitro fertilization program. Fertil Steril 1996;66:430–4.
27.Vezina D, Mauffette F, Roberts KD and Bleau G (1996) Selenium–vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution. Biol Trace Elem Res 53, 65–83.
28.Keskes-Ammar L, Feki-Chakroun N, Rebai T, Sahnoun Z, Ghozzi H, Hammami S, Zghal K, Fki H, Damak J, Bahloul A. Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men. Arch Androl. 2003 Mar-Apr;49(2):83-94.
29.) Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51. Epub 2008 Dec 16.
30. Stankovic H, Mikac-Devic D. Zinc and copper in human semen. Clin Chim Acta 1976;70:123–6.
31. Hartoma TR, Nahoul K, Netter A. Zinc, plasma androgens and male sterility. Lancet 1977;2:1125–6.
32. Stankovic H, Mikac-Devic D. Zinc and copper in human semen. Clin Chim Acta 1976;70:123–6.
33. Kynaston HG, Lewis-Jones DI, Lynch RV, Desmond AD. Changes in seminal quality following oral zinc therapy. Andrologia 1988;20:21–2.
34. Tikkiwal M, Ajmera RL, Mathur NK. Effect of zinc administration on seminal zinc and fertility of oligospermic males. Indian J Physiol Pharmacol 1987;31:30–4.
35. Omu AE, Dashti H, Al-Othman S. Treatment of asthenozoospermia with zinc sulphate: andrological, immunological and obstetric outcome. Eur J Obstet Gynecol Reprod Biol 1998;79:179–84.
36. Colagar AH, Marzony ET, Chaichi MJ.Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men. Nutr Res. 2009 Feb;29(2):82-8.
37. Oliva A, Dotta A, Multigner L. Pentoxifylline and antioxidants improve sperm quality in male patients with varicocele. Fertil Steril. 2009 Apr;91(4 Suppl):1536-9. Epub 2008 Nov 5.
38. Wong WY, Merkus HM, Thomas CM, Menkveld R, Zielhuis GA, Steegers-Theunissen RP. Effects of folic acid and zinc sulfate on male factor subfertility: a double-blind, randomized, placebo-controlled trial. Fertil Steril. 2002 Mar;77(3):491-8.
39. Ebisch IM, Pierik FH, DE Jong FH, Thomas CM, Steegers-Theunissen RP. Does folic acid and zinc sulphate intervention affect endocrine parameters and sperm characteristics in men? Int J Androl. 2006 Apr;29(2):339-45.
40. Omu AE, Al-Azemi MK, Kehinde EO, Anim JT, Oriowo MA, Mathew TC. Indications of the mechanisms involved in improved sperm parameters by zinc therapy. Med Princ Pract. 2008;17(2):108-16. Epub 2008 Feb 19.
41. Sandler B, Faragher B. Treatment of oligospermia with vitamin B12. Infertility 1984;7:133–8.
42. Kumamoto Y, Maruta H, Ishigami J, et al. Clinical efficacy of mecobalamin in treatment of oligozoospermia. Acta Urol Jpn 1988;34:1109–32.
43. Isoyama R, Baba Y, Harada H, et al. Clinical experience of methyl-cobalamin (CH3-B12)/clomiphene citrate combined treatment in male infertility. Hinyokika Kiyo 1986;32:1177–83 [in Japanese].
44.Moriyama H, Nakamura K, Sanda N, Fujiwara E, Seko S, Yamazaki A, Mizutani M, Sagami K, Kitano T. [Studies on the usefulness of a long-term, high-dose treatment of methylcobalamin in patients with oligozoospermia]. Hinyokika Kiyo. 1987 Jan;33(1):151-6.
45.Pront R, Margalioth EJ, Green R, Eldar-Geva T, Maimoni Z, Zimran A, Elstein D.Prevalence of low serum cobalamin in infertile couples. Andrologia. 2009 Feb;41(1):46-50.
46.Peracchi M, Bamonti Catena F, Pomati M, De Franceschi M, Scalabrino G. Human cobalamin deficiency: alterations in serum tumour necrosis factor-alpha and epidermal growth factor. Eur J Haematol. 2001 Aug;67(2):123-7.
47.Boxmeer JC, Smit M, Weber RF, Lindemans J, Romijn JC, Eijkemans MJ, Macklon NS, Steegers-Theunissen RP. Seminal plasma cobalamin significantly correlates with sperm concentration in men undergoing IVF or ICSI procedures. J Androl. 2007 Jul-Aug;28(4):521-7. Epub 2007 Feb 7.
48.) Boxmeer JC, Smit M, Utomo E, Romijn JC, Eijkemans MJ, Lindemans J, Laven JS, Macklon NS, Steegers EA, Steegers-Theunissen RP.Low folate in seminal plasma is associated with increased sperm DNA damage. Fertil Steril. 2008 Aug 21.
49.) Henmi H, Endo T, Kitajima Y, et al. Effects of ascorbic acid supplementation on serum progesterone levels in patients with a luteal phase defect. Fertil Steril 2003;80:459–61.
50.) Du Y, Zhao Y, Ma Y, Bai H, Li X. Clinical observation on treatment of 2,062 cases of immune infertility with integration of traditional Chinese medicine and western medicine.J Tradit Chin Med. 2005 Dec;25(4):278-81.
51.) Chavarro JE, Rich-Edwards JW, Rosner BA, Willett WC. Use of multivitamins, intake of B vitamins, and risk of ovulatory infertility. Fertil Steril. 2008 Mar;89(3):668-76. Epub 2007 Jul 10.
52.) Forges T, Monnier-Barbarino P, Alberto JM, Guéant-Rodriguez RM, Daval JL, Guéant JL. Hum Reprod Update. 2007 May-Jun;13(3):225-38. Epub 2007 Feb 16.
53.) Tamura T, Picciano MF. Folate and human reproduction. Am J Clin Nutr. 2006 May;83(5):993-1016.
54.) Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.
55.) Malone R., Kessenich C.Vitamin D Deficiency: Implications Across the Lifespan. J. for Nurse Practitioners. 2008 Aug.25.