The Enzyme Activator
Zinc is a mineral that functions as a co-factor in numerous metabolic processes. In fact, zinc is a co-factor in over 200 enzymes in the body.
Zinc deficiency is associated with:
- prostate enlargement
- immune deficiency
- malabsorption syndromes
- slow wound healing
- loss of taste or smell
- impaired glucose tolerance
- skin disorders of every type
- Rheumatoid Arthritis (RA)
- inflammatory bowel disease (IBS)
- abnormal menstruation
The adult daily dose range is from 15-50 mg.
Food sources include wheat germ, wheat bran, pumpkin seed, avocado, sea food.
Caution: Large doses (more than 50mg/day) can cause a copper deficiency & other mineral imbalances. Copper should be supplemented when using zinc in high doses.
Optimal daily amounts of Zinc are easily obtained from Dr. Myatt’s Maxi Multi – a comprehensive multiple vitamin and mineral nutrient formula. Click here for full information.
The Premier Fat-Soluble Antioxidant
Vitamin E is the primary fat-soluble antioxidant vitamin in the body. (Vitamin C is the primary water-soluble antioxidant). Vitamin E plays a major role in cellular respiration. Deficiencies of Vitamin E are associated with:
- heart disease
- neurological damage
- muscle weakness
- fibrocystic breast disease
- macular degeneration
- poor wound healing
Dietary sources of Vitamin E include: wheat germ oil, nuts, whole grains, egg yolk.
NOTE: Doses over 800 IU per day of vitamin E may elevate triglycerides.
Maxi Multi provides 400 IU per day of Vitamin E
Those requiring additional Vitamin E supplementation should consider Tocotrienols
What You Should Know (But Have Not been Told) About Your Drinking Water
- Water is essential for good health
- your drinking and bathing water may be contaminated
- water contaminants are linked to a wide variety of illnesses
- how you can protect yourself from impure water
Every Body Needs Water
57-70% of adult human body weight is water. Every cell in the body is dependent on water for survival and optimal function. Consider a few of the many important functions of body water:
- maintenance of normal skin tone (dehydrated skin appears wrinkled
- maintenance of normal bowel function (lack of water is a common cause of constipation
- maintenance of normal urinary tract function (lack of water can lead to urinary tract infection, urinary frequency, kidney stones and bladder cancer)
- maintenance of normal muscle tone
- maintenance of normal fluid balance (dehydration leads to water retention; sufficient water acts as a diuretic)
- maintenance of normal digestion (many nutrients are transported via the body’s water)
- elimination of toxins (lungs, kidneys, skin and intestinal tract all depend on water for eliminative functions)
- joints require sufficient water to make the “jello” (glycosaminoglycands) that provide cushioning
Your Best Bet for Safe Drinking Water
Your best bet for safe, clean drinking water is install an under-sink or countertop water purifier. The reverse-osmosis type is very reliable. If you don’t want to invest the money to do that, a simple pitcher with a charcoal filter is better than most bottled water. You can see how different systems stack up with this brand comparison chart.
And don’t forget your shower-water! When you’re hot (and your skin’s pores are wide-open), you can absorb toxins from the water. Shower filters are inexpensive and reliable.
For maximum protection, whole house water filters are the ultimate safeguard against water-borne toxins and impurities. These are not inexpensive but they offer great peace of mind.
A Good Water Filter is a Cheap Investment in Your Health
A reliable, highly-effective under-sink water filter is an excellent health investment, especially when you consider how important water is to health. The human body is about 60% water. That means we can have 60% of our total body weight contaminated with a variety of toxins if we drink lousy water.
The highest-rated water filters cost about the same as the cheap junk.
Aquasana Water Purifiers makes some of the highest-rated filters at the best prices.
Regular (annual) testing of your family’s drinking water is a wise investment in good health – especially if you are drinking municipal water that has been “treated”, flouridated and chlorinated! Well-water is also subject to contamination from a variety of sources and must be tested annually to ensure your family’s safety.
- Smoking weakens the immune system by inhibiting cellular immunity.
- Tobacco smoke contains carbon monoxide, a substance that is toxic to the brain.
- Tobacco smoking is associated with a higher incidence of gingivitis and tooth loss.
- Tobacco smoke contains cadmium, a heavy metal that can cause high blood pressure, kidney stones, and other toxic symptoms.
- Tobacco smoke induces the formation of free radicals – highly reactive molecules that can bind to normal, healthy cells and destroy them.
- Smokers have a higher incidence of peptic ulcer disease, a decreased response to anti-ulcer medications, and a higher mortality from peptic ulcer.
- Female smokers are at higher risk of developing osteoporosis.
- Female smokers are at higher risk for premature menopause.
- Smoking accelerates skin aging and wrinkle formation.
- Smoking causes a decrease in penile blood flow and can cause impotence in males.
- Smokers have a three to five-fold increase in coronary artery disease compared to non-smokers.
- Smoking is associated with the development of urinary tract cancer, bowel cancer, pancreatic cancer, cervical and uterine cancer – and yes, lung cancer.
- Smoking is a potent risk factor for atherosclerosis.
- 40% of heavy smokers die before they reach retirement age.
- Nicotine causes adrenaline release, which can cause anxiety, heart palpitations, diarrhea, and high blood pressure.
- Hydrogen cyanide, a chemical in tobacco smoke, causes inflammation of the bronchi which leads to bronchitis. Chronic obstructive pulmonary disease and emphysema often eventually result.
- The adrenal stimulation caused by nicotine can aggravate hypoglycemia. Eventually, adrenal exhaustion results.
- The American Lung Association reports that 350,000 Americans die each year from cigarette smoking. This is more than the combined deaths from illegal drugs, traffic accidents, suicide, homicide, and alcohol.
Don’t Kid Yourself.
Smoking tobacco is incompatible with a healthy lifestyle.
Natural Prevention Strategies
The term “stroke” refers to a cerebrovascular accident (CVA) where the brain is deprived of oxygen due to blood vessel blockage (80% of strokes) OR the rupture of a blood vessel which causes bleeding in the brain (20% of strokes). Either of these events deprives areas of the brain of oxygen and can lead to neurological damage. A transient ischemic attack (TIA) is a similar, smaller event, resolving in minutes to hours and without permanent damage. Recurrent TIA’s often precede a true stroke, and the causes of both are the same. Stroke (Cerebrovascular disease) is the most common cause of neurologic disability in Western countries.
Twenty percent of strokes are hemorrhagic, resulting from the rupture of a cerebral artery. Causes of hemorrhagic stroke include hypertension, aneurysm, blood vessel defects (inborn) and excess blood-thinning medication.
The remaining eighty percent of strokes are due to blockages resulting from emboli (a clump of blood cells or atherosclerotic plaque) in a cranial artery. Causes of infarct stroke are atherosclerosis, high blood pressure, excess blood-clotting factors (see “conditions predisposing to blood clot formation,” below), blood turbulence (due to arrhythmias, heart valve defects, arteriovenous malformation, and atherosclerosis), diabetes, and vascular inflammation.
A far lesser number of strokes may be due solely to lack of oxygen without a blockage, usually due to sympathomimetic drugs (cocaine, amphetamine), arterial compression caused by bone spurs, or circulatory insufficiency due to decreased overall circulation.
“Thrombosis” refers to a blood clot that develops in a blood vessel. It is one of the leading causes of death in the Western world.
If a thrombosis forms in a coronary artery, a myocardial infarction may result. When thromboses form in the brain, the resultant oxygen deprivation may result in TIA or stroke. An emboli occurs when a clot breaks free and travels to other parts of the body. If an emboli reaches the brain, again, stroke may occur. Thromboses and emboli can also cause serious damage to lungs, kidneys — in fact, virtually any organ.
Phlebitis / Thrombophlebitis
“Thrombophlebitis,” or deep venous thrombosis (DVT) is the most common presenting vein disorder. Most vein clots begin in the valves of deep calf veins. Tissue substances are released that in turn form clumps of red blood cells (RBC’s). If these clumped blood cells remain in the leg or elsewhere, they cause redness, swelling, and pain. If they dislodge and travel to the brain, they can cause a stroke.
Causes of venous thrombosis include:
- Blood vessel lining injury (caused by catheters, septic phlebitis, injection of irritating substances, trauma).
- Excess blood clotting (due to malignant tumors, blood cell abnormalities, oral contraceptives and inflammation).
- Slowed blood flow (varicose veins, prolonged bed rest, heart failure, dependent immobilization of the legs such as occurs during car or air travel).
Factors which can cause blood clots
Specifically, any one of the following conditions may predispose to blood clot formation:
- elevated homocysteine levels
- oxidized LDL cholesterol levels
- platelet activating factor (PAF)
- elevated fibrinogen
- elevated thromboxane A2, prostaglandin E2, lipooxygenase, cyclooxygenase
- free-radical induced platelet aggregation
- thrombin activating factor
- deficiency of tissue-plasminogen activator (tPA)
- increased blood viscosity
- increased platelet count
- increased red blood cell kinase activity
- inflammation of the arterial wall
- atherosclerotic plaque
- elevated triglycerides
- increased platelet adhesion
- collagen-induced platelet adhesion
- arachidonic acid-induced platelet aggregation
- adenosine-induced platelet aggregation
- epinephrine-induced platelet aggregation
- serotonin-induced platelet aggregation
- antigen-antibody reactions
Fibrin thrombi can be prevented by conventional anticoagulant therapy (heparin or coumarin / coumadin / warfarin compounds), but platelet aggregation is not inhibited by these agents. (Merck Manual p. 586). It is estimated that only 1/3 of all causative agents of thrombosis are blocked by the administration of conventional blood thinning drugs.
Treatment of the underlying cause of thrombosis, and phlebitis which results in thrombosis, are the mainstays of prevention of stroke occurrence and reoccurrence. High blood pressure, high cholesterol (especially with low HDL- the “good” cholesterol), excessive blood clotting (“blood sludge”), and atherosclerosis should be addressed as indicated. Because of the many and varied causes of thrombosis, a multi-faceted approach to anticoagulation and blood viscosity normalization is surer than conventional anticoagulant (coumadin) therapy alone.
Diet and Lifestyle Recommendations
- Diet: eat a nutritious diet high in nutrient-rich foods. Plant foods contain phytonutrients which help prevent blood from clotting abnormally.
- Achieve and maintain a normal weight.
- Exercise regularly. 30 minutes, 3 times per week minimum.
- Don’t smoke! Smoking irritates the blood vessel lining and such irritation initiates a chain of events that cause blood to clump.
- Drink 64 ounces of pure water daily. Dehydration causes blood vessel irritation and can predispose to abnormal blood clotting.
- Maxi Multi: 3 caps, 3 times per day with meals. Optimal (not minimal) doses of antioxidant nutrients (vitamin A, beta carotene, C, E, zinc, selenium), B6, B12, folic acid, bioflavonoids and magnesium are especially important. Magnesium helps prevent high blood pressure, a cause of stroke.
- Omega 3 fatty acids: the anti-inflammatory action of Omega-3’s helps prevent blood vessel irritation.
Flax seed meal, 2 teaspoons per day with food
Flax seed capsules: 2-4 caps, 3 times per day (target dose range: 6-12 caps per day)
Flax seed oil : 1 tablespoon per day
- MAXI-GREENS: 3 caps, 3 times per day. Maxi greens contains a spectrum of the herbs known to maintain normal blood viscosity. (grape seed, ginkgo, bilberry, green tea).
(Treat known risk factors. Consult an alternative medicine physician for further assistance):
High Cholesterol or Triglyceride levels:
- Follow additional recommendations for High Cholesterol
Diabetes (which predisposes to atherosclerosis):
- Follow additional recommendations for Diabetes
- Follow additional recommendations for Atherosclerosis
High homocysteine levels:
- B6, B12 and folic acid. (NOTE: Maxi Multi contains optimal doses of these nutrients. Take additional B6, B12 and folic acid only if you are not taking Maxi Multi, MyPacks or the equivalent).
High ferritin (storage iron):
- Vitamin C: 5,000 mg per day in divided doses.
- Grape seed extract: 150 mg per day.
Primary Materia Medica for Stroke Prevention
(Professional descriptions follow. For laymen description of these same herbs, please refer to Twelve Important Herbs to Know )
The following list represents the most well-researched herbs for stroke prevention:
Garlic Allium sativa
Garlic is one of the most important cardiovascular botanicals and best documented blood-thinning agents. It protects against collagen-induced, arachidonic acid-induced, ADP-induced, and epinephrine-induced platelet aggregation. Garlic inhibits cyclooxygenase and lipooxygenase-induced thromboxane A2 synthesis. Clinical studies have also documented garlic’s effectiveness in treating many factors involved in atherosclerosis, including high blood pressure, high LDL-cholesterol, and high triglycerides. Garlic decreases platelet aggregation while simultaneously increasing HDL cholesterol and fibrinolysis.
Ginkgo Ginkgo biloba
Ginkgo exerts considerable effect on platelet aggregation, adhesion and degranulation. Specifically, ginkgo inhibits platelet activating factor (PAF) and reduces platelet aggregation induced by ADP, collagen, and arachidonic acid. It has membrane-stabilizing, antioxidant and free radical scavenging effects, and improves blood flow, oxygen and glucose utilization in the brain. Ginkgo biloba extract (GBE) stimulates endothelium-derived relaxing factor (EDRF) and prostacycline. In animal studies, GBE has shown to stimulate nerve cell regeneration, making it potentially useful both for stroke prevention and post-stroke treatment.
Curcumin, the yellow pigment of Curcuma longa, has potent anti-inflammatory and antioxidant effects. It inhibits platelet aggregation by inhibiting thromboxanes and leukotrienes and promoting the formation of prostacycline.
<Bromelain Anasas comosus
Bromelain is a mixture of enzymes found primarily in the stem of the pineapple plant. It exerts antiinflammatory effects by inhibition of pro-inflammatory prostaglandins. Bromelain blocks production of kinnins and possesses fibrinolytic activity secondary to plasminogen activator, which may also account for the anti-metastatic properties seen in vivo.
Bilberry Vaccinium myrtillus
The flavonoids in Bilberry, specifically anthocyanosides, promote prostacycline production and inhibit platelet aggregation in a manner similar to ginkgo. The potent antioxidant effects seen in this herb stabilize the vascular system and are therefore useful in treating capillary fragility, venous insufficiency, and varicose veins.
Grape Seed Vitus vinifera
Oligomeric proanthocyanidin complexes (OPC’s) from grape seed and other species, such as Landis’ pine, is one of the most potent antioxidants known. OPC’s trap reactive oxygen species including hydroxyl radicals, peroxyl radicals, and lipid radicals; they also delay the breakdown phase of lipid peroxidation. OPC’s inhibit platelet aggregation in part by raising cGMP levels and protecting against epinephrine renewed cyclic flow reductions. In addition, OPC’s inhibit certain proteolytic enzymes, including collagenase, elastase, beta-glucuronidase and hyaluronidase which can damage the extracellular matrix surrounding capillary walls. This makes OPC’s a useful choice for improving vascular fragility and peripheral vascular insufficiency which can lead to thrombophlebitis.
A 5-Point Program to Stop Smoking for Good
Chronic (daily) tobacco use (smoking or chewing) is one of the most health-harming habits anyone can engage in. (Daily bungee-jumping might be more harmful). And it’s not “just” lung disease: the effects of smoking cause premature aging and damage from head to toe.
In case you don’t know about the other “non-lung” problems caused by smoking, read Smoking: Just the Facts^ (The link opens in a new window). Then come back here to learn what you can do to either:
A.) help protect yourself from many of the harmful effects of tobacco use,
OR (better yet)
B.) stop smoking altogether.
Tobacco is a highly addictive substance. Some say that it is one of the most difficult drugs to quit. Here is my 5-point plan for making your “stop smoking” decision easier and surer.
1.) Decide on a “quit date.” Whether you plan on decreasing your tobacco use gradually or quitting “cold turkey,” have a “quit date” selected and stick to it.
In practice, I have observed higher success rates among those who quit “cold turkey,” but pick a plan and stick with it no matter which method you choose.
2.) Keep a “smoking triggers” diary for one week. Write down when you tend to smoke. Is it on work-break? After meals? When driving?
Whatever your “triggers” are, you’ll need to plan alternate activities. For example, if you usually smoke at work breaks, plan to take a brief walk around the building or outdoor area instead.
Nature abhors a vacuum. If you don’t have other activities planned, you’ll revert to your habitual “smoking times,” even when you don’t physically crave a cigarette.
3.) Take a high-quality multiple Vitamin/Mineral Supplement. Smoking depletes B complex vitamins, antioxidants and other nutrients. These nutrients not only protect from some of the harmful effects of smoking, but they are involved in the production of neurotransmitters.
Imbalances in neurotransmitters – aka “brain hormones” – are a common cause of cravings. Taking a high quality multiple vitamin/mineral formula helps balance these brain chemicals and reduce cravings during withdrawal from tobacco.
NOTE: You need an Optimal Dose vitamin formula (6-9 capsules per day), not a “minimal Dose one-per-day formula. Here is a chart to show you optimal doses of individual nutrients: Optimal Dose Vitamins and Minerals
4.) Neurotransmitter Testing. Smoking alters the levels of Neurotransmitters (NT’s). It may also be that alterations in NT levels contribute to initial tobacco addiction.
For example: some people smoke because it increases energy levels. Low energy, in turn, can be cause by low epinephrine (adrenaline) and norepinephrine (nor-adrenaline) NT levels. If these NT levels are low, normalizing them by natural methods can overcome the “energy rush’ offered by smoking.
Serotonin, epinephrine, norepinephrine, dopamine, GABA, PEA and histamine can all be involved in the addiction/craving cycle. A simple urine test which measures levels of these important “head hormones” can allow us to balance brain chemistry naturally and break the addictive cycle without low energy, nervousness and other symptoms many “quitters” experience.
Natural alternatives to “head meds” exist, and they can be used to balance brain chemistry once the results of your test are in.
5.) “How Bad Do You Want It”? as the Don Henley tune asks
Make sure your list of “why I want to quit” is a strong one. You’ll use this to remind yourself to stay firm when waves of cravings roll through.
It’s fine to want to quit for someone else, but be sure to have some “me” reasons on the list as well. Here are a few to get you started. Feel free to use any of those that apply to you!
Save money, improve breathing, decrease risk of heart disease, slow the aging process, live long enough to enjoy retirement (or the grandkids), set a good example for the grandkids (or your own children), not smell like stale smoke all the time, be free of addiction, have more energy, move with greater ease.
By following this 5-point program, anyone who really wants to quit can do so. I’ve got hundreds of successful “quitters” in my practice, a testimony to the success of this program and the power of genuine motivation.
Dr. Myatt is pleased to present, by special arrangement and permission, the following article by noted scientists and authors Sally Fallon and Mary Enig, PhD.
Dangers of Statin Drugs: What You Haven’t Been Told About Popular Cholesterol-Lowering Medicines
By Sally Fallon and Mary G. Enig, PhD
Hypercholesterolemia is the health issue of the 21st century. It is actually an invented disease, a “problem” that emerged when health professionals learned how to measure cholesterol levels in the blood. High cholesterol exhibits no outward signs–unlike other conditions of the blood, such as diabetes or anemia, diseases that manifest telltale symptoms like thirst or weakness–hypercholesterolemia requires the services of a physician to detect its presence. Many people who feel perfectly healthy suffer from high cholesterol–in fact, feeling good is actually a symptom of high cholesterol!
Doctors who treat this new disease must first convince their patients that they are sick and need to take one or more expensive drugs for the rest of their lives, drugs that require regular checkups and blood tests. But such doctors do not work in a vacuum–their efforts to convert healthy people into patients are bolstered by the full weight of the US government, the media and the medical establishment, agencies that have worked in concert to disseminate the cholesterol dogma and convince the population that high cholesterol is the forerunner of heart disease and possibly other diseases as well.
Who suffers from hypercholesterolemia? Peruse the medical literature of 25 or 30 years ago and you’ll get the following answer: any middle-aged man whose cholesterol is over 240 with other risk factors, such as smoking or overweight. After the Cholesterol Consensus Conference in 1984, the parameters changed; anyone (male or female) with cholesterol over 200 could receive the dreaded diagnosis and a prescription for pills. Recently that number has been moved down to 180. If you have had a heart attack, you get to take cholesterol-lowering medicines even if your cholesterol is already very low–after all, you have committed the sin of having a heart attack so your cholesterol must therefore be too high. The penance is a lifetime of cholesterol-lowering medications along with a boring lowfat diet. But why wait until you have a heart attack? Since we all labor under the stigma of original sin, we are all candidates for treatment. Current edicts stipulate cholesterol testing and treatment for young adults and even children.
The drugs that doctors use to treat the new disease are called statins–sold under a variety of names including Lipitor (atorvastatin), Zocor (simvastatin), Mevacor (lovastatin) and Pravachol (pravastatin).
How Statins Work
The diagram below illustrates the pathways involved in cholesterol production. The process begins with acetyl-CoA, a two-carbon molecule sometimes referred to as the “building block of life.” Three acetyl-CoA molecules combine to form six-carbon hydroxymethyl glutaric acid (HMG). The step from HMG to mevalonate requires an enzyme, HMG-CoA reductase. Statin drugs work by inhibiting this enzyme–hence the formal name of HMG-CoA reductase inhibitors. Herein lies the potential for numerous side effects, because statin drugs inhibit not just the production of cholesterol, but a whole family of intermediary substances, many if not all of which have important biochemical functions in their own right.
Consider the findings of pediatricians at the University of California, San Diego who published a description of a child with an hereditary defect of mevalonic kinase, the enzyme that facilitates the next step beyond HMG-CoA reductase.1 The child was mentally retarded, microcephalic (very small head), small for his age, profoundly anemic, acidotic and febrile. He also had cataracts. Predictably, his cholesterol was consistently low–70-79 mg/dl. He died at the age of 24 months. The child represents an extreme example of cholesterol inhibition, but his case illuminates the possible consequences of taking statins in strong doses or for a lengthy period of time–depression of mental acuity, anemia, acidosis, frequent fevers and cataracts.
Cholesterol is one of three end products in the mevalonate chain. The two others are ubiquinone and dilochol. Ubiquinone or Co-Enzyme Q10 is a critical cellular nutrient biosynthesized in the mitochondria. It plays a role in ATP production in the cells and functions as an electron carrier to cytochrome oxidase, our main respiratory enzyme. The heart requires high levels of Co-Q10. A form of Co-Q10 called ubiquinone is found in all cell membranes where it plays a role in maintaining membrane integrity so critical to nerve conduction and muscle integrity. Co-Q10 is also vital to the formation of elastin and collagen. Side effects of Co-Q10 deficiency include muscle wasting leading to weakness and severe back pain, heart failure (the heart is a muscle!), neuropathy and inflammation of the tendons and ligaments, often leading to rupture.
What About Aspirin?
The other drug recommended for prevention of heart attacks and strokes is aspirin. Estimates suggest that 20 million persons are taking aspirin daily for prevention of vascular accidents. Yet at least four studies have shown no benefit. A study using Bufferin (aspirin and magnesium) showed no reduction in fatal heart attacks and no improvement in survival rate but a 40 percent decrease in the number of nonfatal heart attacks. Commentators reported these results as showing the benefit of aspirin, ignoring the fact that magnesium is of proven benefit in heart disease. Aspirin inhibits the enzyme Delta-6 Desaturase, needed for the production of Gamma-Linoleic Acid (GLA) and important anti-inflammatory prostaglandins. This fact explains many of aspirin’s side effects, including gastrointestinal bleeding and increased risk of macular degeneration and cataract formation. Other side effects include increased risk of pancreatic cancer, acid reflux, asthma attacks, kidney damage, liver problems, ulcers, anemia, hearing loss, allergic reactions, vomiting, diarrhea, dizziness and even hallucinations (James Howenstine, NewsWithViews.com, April 21, 2004).
Dolichols also play a role of immense importance. In the cells they direct various proteins manufactured in response to DNA directives to their proper targets, ensuring that the cells respond correctly to genetically programmed instruction. Thus statin drugs can lead to unpredictable chaos on the cellular level, much like a computer virus that wipes out certain pathways or files.
Squalene, the immediate precursor to cholesterol, has anti-cancer effects, according to research.
The fact that some studies have shown that statins can prevent heart disease, at least in the short term, is most likely explained not by the inhibition of cholesterol production but because they block the creation of mevalonate. Reduced amounts of mevalonate seem to make smooth muscle cells less active, and platelets less able to produce thromboxane. Atherosclerosis begins with the growth of smooth muscle cells in side artery walls and thromboxane is necessary for blood clotting.
Of course, statins inhibit the production of cholesterol–they do this very well. Nowhere is the failing of our medical system more evident than in the wholesale acceptance of cholesterol reduction as a way to prevent disease–have all these doctors forgotten what they learned in biochemistry 101 about the many roles of cholesterol in the human biochemistry? Every cell membrane in our body contains cholesterol because cholesterol is what makes our cells waterproof–without cholesterol we could not have a different biochemistry on the inside and the outside of the cell. When cholesterol levels are not adequate, the cell membrane becomes leaky or porous, a situation the body interprets as an emergency, releasing a flood of corticoid hormones that work by sequestering cholesterol from one part of the body and transporting it to areas where it is lacking. Cholesterol is the body’s repair substance: scar tissue contains high levels of cholesterol, including scar tissue in the arteries.
Doctors and other health professionals claim there is ample proof that animal fats cause heart disease while they confidently advise us to adopt a lowfat diet; actually the literature contains only two studies involving humans that compared the outcome (not markers like cholesterol levels) of a diet high in animal fat with a diet based on vegetable oils, and both showed that animal fats are protective.
The Anti-Coronary Club project, launched in 1957 and published in 1966 in the Journal of the American Medical Association, compared two groups of New York businessmen, aged 40 to 59 years. One group followed the so-called “Prudent Diet” consisting of corn oil and margarine instead of butter, cold breakfast cereals instead of eggs and chicken and fish instead of beef; a control group ate eggs for breakfast and meat three times per day. The final report noted that the Prudent Dieters had average serum cholesterol of 220 mg/l, compared to 250 mg/l in the eggs-and-meat group. But there were eight deaths from heart disease among Prudent Dieter group, and none among those who ate meat three times a day
In a study published in the British Medical Journal, 1965, patients who had already had a heart attack were divided into three groups: one group got polyunsaturated corn oil, the second got monounsaturated olive oil and the third group was told to eat animal fat. After two years, the corn oil group had 30 percent lower cholesterol, but only 52 percent of them were still alive. The olive oil groups fared little better–only 57 percent were alive after two years. But of the group that ate mostly animal fat, 75 percent were still alive after two years.
Cholesterol is the precursor to vitamin D, necessary for numerous biochemical processes including mineral metabolism. The bile salts, required for the digestion of fat, are made of cholesterol. Those who suffer from low cholesterol often have trouble digesting fats. Cholesterol also functions as a powerful antioxidant, thus protecting us against cancer and aging.
Cholesterol is vital to proper neurological function. It plays a key role in the formation of memory and the uptake of hormones in the brain, including serotonin, the body’s feel-good chemical. When cholesterol levels drop too low, the serotonin receptors cannot work. Cholesterol is the main organic molecule in the brain, constituting over half the dry weight of the cerebral cortex.
Finally, cholesterol is the precursor to all the hormones produced in the adrenal cortex including glucocorticoids, which regulate blood sugar levels, and mineralocorticoids, which regulate mineral balance. Corticoids are the cholesterol-based adrenal hormones that the body uses in response to stress of various types; it promotes healing and balances the tendency to inflammation. The adrenal cortex also produces sex hormones, including testosterone, estrogen and progesterone, out of cholesterol. Thus, low cholesterol–whether due to an innate error of metabolism or induced by cholesterol-lowering diets and drugs–can be expected to disrupt the production of adrenal hormones and lead to blood sugar problems, edema, mineral deficiencies, chronic inflammation, difficulty in healing, allergies, asthma, reduced libido, infertility and various reproductive problems.
Enter the Statins
Statin drugs entered the market with great promise. They replaced a class of pharmaceuticals that lowered cholesterol by preventing its absorption from the gut. These drugs often had immediate and unpleasant side effects, including nausea, indigestion and constipation, and in the typical patient they lowered cholesterol levels only slightly. Patient compliance was low: the benefit did not seem worth the side effects and the potential for use very limited. By contrast, statin drugs had no immediate side effects: they did not cause nausea or indigestion and they were consistently effective, often lowering cholesterol levels by 50 points or more. During the last 20 years, the industry has mounted an incredible promotional campaign–enlisting scientists, advertising agencies, the media and the medical profession in a blitz that turned the statins into one of the bestselling pharmaceuticals of all time. Sixteen million Americans now take Lipitor, the most popular statin, and drug company officials claim that 36 million Americans are candidates for statin drug therapy. What bedevils the industry is growing reports of side effects that manifest many months after the commencement of therapy; the November 2003 issue of Smart Money magazine reports on a 1999 study at St. Thomas’ Hospital in London (apparently unpublished), which found that 36 percent of patients on Lipitor’s highest dose reported side effects; even at the lowest dose, 10 percent reported side effects.2
Muscle Pain and Weakness
The most common side effect is muscle pain and weakness, a condition called rhabdomyolysis, most likely due to the depletion of Co-Q10, a nutrient that supports muscle function. Dr. Beatrice Golomb of San Diego, California is currently conducting a series of studies on statin side effects. The industry insists that only 2-3 percent of patients get muscle aches and cramps but in one study, Golomb found that 98 percent of patients taking Lipitor and one-third of the patients taking Mevachor (a lower-dose statin) suffered from muscle problems.3 A message board devoted to Lipitor at forum.ditonline.com (update 09 JUL 2007: reader alerted us the forum is now defunct) contained more than 800 posts, many detailing severe side effects. The Lipitor board at www.rxlist.com contains more than 2,600 posts (click on Message Boards at upper left and then choose Lipitor; also note that as of 09 JUL 2007 there are 3,857 messages).
The test for muscle wasting or rhabdomyolysis is elevated levels of a chemical called creatine kinase (CK). But many people experience pain and fatigue even though they have normal CK levels.4
Tahoe City resident Doug Peterson developed slurred speech, balance problems and severe fatigue after three years on Lipitor–for two and a half years, he had no side effects at all.5 It began with restless sleep patterns–twitching and flailing his arms. Loss of balance followed and the beginning of what Doug calls the “statin shuffle”–a slow, wobbly walk across the room. Fine motor skills suffered next. It took him five minutes to write four words, much of which was illegible. Cognitive function also declined. It was hard to convince his doctors that Lipitor could be the culprit, but when he finally stopped taking it, his coordination and memory improved.
John Altrocchi took Mevacor for three years without side effects; then he developed calf pain so severe he could hardly walk. He also experienced episodes of temporary memory loss.
For some, however, muscle problems show up shortly after treatment begins. Ed Ontiveros began having muscle problems within 30 days of taking Lipitor. He fell in the bathroom and had trouble getting up. The weakness subsided when he went off Lipitor. In another case, reported in the medical journal Heart, a patient developed rhabdomyolysis after a single dose of a statin.6 Heel pain from plantar fascitis (heel spurs) is another common complaint among those taking statin drugs. One correspondent reported the onset of pain in the feet shortly after beginning statin treatment. She had visited an evangelist, requesting that he pray for her sore feet. He enquired whether she was taking Lipitor. When she said yes, he told her that his feet had also hurt when he took Lipitor.7
Active people are much more likely to develop problems from statin use than those who are sedentary. In a study carried out in Austria, only six out of 22 athletes with familial hypercholesterolemia were able to endure statin treatment.8 The others discontinued treatment because of muscle pain.
By the way, other cholesterol-lowering agents besides statin drugs can cause joint pain and muscle weakness. A report in Southern Medical Journal described muscle pains and weakness in a man who took Chinese red rice, an herbal preparation that lowers cholesterol.9 Anyone suffering from myopathy, fibromyalgia, coordination problems and fatigue needs to look at low cholesterol plus Co-Q10 deficiency as a possible cause.
Polyneuropathy, also known as peripheral neuropathy, is characterized by weakness, tingling and pain in the hands and feet as well as difficulty walking. Researchers who studied 500,000 residents of Denmark, about 9 percent of that country’s population, found that people who took statins were more likely to develop polyneuropathy.10 Taking statins for one year raised the risk of nerve damage by about 15 percent–about one case for every 2,200 patients. For those who took statins for two or more years, the additional risk rose to 26 percent.
According to the research of Dr. Golomb, nerve problems are a common side effect from statin use; patients who use statins for two or more years are at a four to 14-fold increased risk of developing idiopathic polyneuropathy compared to controls.11 She reports that in many cases, patients told her they had complained to their doctors about neurological problems, only to be assured that their symptoms could not be related to cholesterol-lowering medications.
The damage is often irreversible. People who take large doses for a long time may be left with permanent nerve damage, even after they stop taking the drug.
The question is, does widespread statin-induced neuropathy make our elderly drivers (and even not-so-elderly drivers) more accident prone? In July of 2003, an 86-year-old driver with an excellent driving record plowed into a farmers’ market in Santa Monica, California, killing 10 people. Several days later, a most interesting letter from a Lake Oswego, Oregon woman appeared in the Washington Post:12
“My husband, at age 68, backed into the garage and stepped on the gas, wrecking a lot of stuff. He said his foot slipped off the brake. He had health problems and is on medication, including a cholesterol drug, which is now known to cause problems with feeling in one’s legs.
“In my little community, older drivers have missed a turn and taken out the end of a music store, the double doors of the post office and the front of a bakery. In Portland, a bank had to do without its drive-up window for some time.
“It is easy to say that one’s foot slipped, but the problem could be lack of sensation. My husband’s sister-in-law thought her car was malfunctioning when it refused to go when a light turned green, until she looked down and saw that her food was on the brake. I have another friend who mentioned having no feeling in her lower extremities. She thought about having her car retrofitted with hand controls but opted for the handicapped bus instead.”
We are currently in the midst of a congestive heart failure epidemic in the United States–while the incidence of heart attack has declined slightly, an increase in the number heart failure cases has outpaced these gains. Deaths attributed to heart failure more than doubled from 1989 to 1997.13 (Statins were first given pre-market approval in 1987.) Interference with production of Co-Q10 by statin drugs is the most likely explanation. The heart is a muscle and it cannot work when deprived of Co-Q10.
Cardiologist Peter Langsjoen studied 20 patients with completely normal heart function. After six months on a low dose of 20 mg of Lipitor a day, two-thirds of the patients had abnormalities in the heart’s filling phase, when the muscle fills with blood. According to Langsjoen, this malfunction is due to Co-Q10 depletion. Without Co-Q10, the cell’s mitochondria are inhibited from producing energy, leading to muscle pain and weakness. The heart is especially susceptible because it uses so much energy.14
Co-Q10 depletion becomes more and more of a problem as the pharmaceutical industry encourages doctors to lower cholesterol levels in their patients by greater and greater amounts. Fifteen animal studies in six different animal species have documented statin-induced Co-Q10 depletion leading to decreased ATP production, increased injury from heart failure, skeletal muscle injury and increased mortality. Of the nine controlled trials on statin-induced Co-Q10 depletion in humans, eight showed significant Co-Q10 depletion leading to decline in left ventricular function and biochemical imbalances.15
Yet virtually all patients with heart failure are put on statin drugs, even if their cholesterol is already low. Of interest is a recent study indicating that patients with chronic heart failure benefit from having high levels of cholesterol rather than low. Researchers in Hull, UK followed 114 heart failure patients for at least 12 months.16 Survival was 78 percent at 12 months and 56 percent at 36 months. They found that for every point of decrease in serum cholesterol, there was a 36 percent increase in the risk of death within 3 years.
Dizziness is commonly associated with statin use, possibly due to pressure-lowering effects. One woman reported dizziness one half hour after taking Pravachol.17 When she stopped taking it, the dizziness cleared up. Blood pressure lowering has been reported with several statins in published studies. According to Dr. Golumb, who notes that dizziness is a common adverse effect, the elderly may be particularly sensitive to drops in blood pressure.18
The November 2003 issue of Smart Money19 describes the case of Mike Hope, owner of a successful ophthalmologic supply company: “There’s an awkward silence when you ask Mike Hope his age. He doesn’t change the subject or stammer, or make a silly joke about how he stopped counting at 21. He simply doesn’t remember. Ten seconds pass. Then 20. Finally an answer comes to him. ‘I’m 56,’ he says. Close, but not quite. ‘I will be 56 this year.’ Later, if you happen to ask him about the book he’s reading, you’ll hit another roadblock. He can’t recall the title, the author or the plot.” Statin use since 1998 has caused his speech and memory to fade. He was forced to close his business and went on Social Security 10 years early. Things improved when he discontinued Lipitor in 2002, but he is far from complete recovery–he still cannot sustain a conversation. What Lipitor did was turn Mike Hope into an old man when he was in the prime of life.
Cases like Mike’s have shown up in the medical literature as well. An article in Pharmacotherapy, December 2003, for example, reports two cases of cognitive impairment associated with Lipitor and Zocor.20 Both patients suffered progressive cognitive decline that reversed completely within a month after discontinuation of the statins. A study conducted at the University of Pittsburgh showed that patients treated with statins for six months compared poorly with patients on a placebo in solving complex mazes, psychomotor skills and memory tests.21
Dr. Golomb has found that 15 percent of statin patients develop some cognitive side effects.22 The most harrowing involve global transient amnesia–complete memory loss for a brief or lengthy period–described by former astronaut Duane Graveline in his book Lipitor: Thief of Memory.23 Sufferers report baffling incidents involving complete loss of memory–arriving at a store and not remembering why they are there, unable to remember their name or the names of their loved ones, unable to find their way home in the car. These episodes occur suddenly and disappear just as suddenly. Graveline points out that we are all at risk when the general public is taking statins–do you want to be in an airplane when your pilot develops statin-induced amnesia?
While the pharmaceutical industry denies that statins can cause amnesia, memory loss has shown up in several statin trials. In a trial involving 2502 subjects, amnesia occurred in 7 receiving Lipitor; amnesia also occurred in 2 of 742 subjects during comparative trials with other statins. In addition, “abnormal thinking” was reported in 4 of the 2502 clinical trial subjects.24 The total recorded side effects was therefore 0.5 percent; a figure that likely under-represents the true frequency since memory loss was not specifically studied in these trials.
In every study with rodents to date, statins have caused cancer.25 Why have we not seen such a dramatic correlation in human studies? Because cancer takes a long time to develop and most of the statin trials do not go on longer than two or three years. Still, in one trial, the CARE trial, breast cancer rates of those taking a statin went up 1500 percent.26 In the Heart Protection Study, non-melanoma skin cancer occurred in 243 patients treated with simvastatin compared with 202 cases in the control group.27
Manufacturers of statin drugs have recognized the fact that statins depress the immune system, an effect that can lead to cancer and infectious disease, recommending statin use for inflammatory arthritis and as an immune suppressor for transplant patients.28
The medical literature contains several reports of pancreatitis in patients taking statins. One paper describes the case of a 49-year-old woman who was admitted to the hospital with diarrhea and septic shock one month after beginning treatment with lovastatin.29 She died after prolonged hospitalization; the cause of death was necrotizing pancreatitis. Her doctors noted that the patient had no evidence of common risk factors for acute pancreatitis, such as biliary tract disease or alcohol use. “Prescribers of statins (particularly simvastatin and lovastatin) should take into account the possibility of acute pancreatitis in patients who develop abdominal pain within the first weeks of treatment with these drugs,” they warned.
Numerous studies have linked low cholesterol with depression. One of the most recent found that women with low cholesterol are twice as likely to suffer from depression and anxiety. Researchers from Duke University Medical Center carried out personality trait measurements on 121 young women aged 18 to 27.30 They found that 39 percent of the women with low cholesterol levels scored high on personality traits that signalled proneness to depression, compared to 19 percent of women with normal or high levels of cholesterol. In addition, one in three of the women with low cholesterol levels scored high on anxiety indicators, compared to 21 percent with normal levels. Yet the author of the study, Dr. Edward Suarez, cautioned women with low cholesterol against eating “foods such as cream cakes” to raise cholesterol, warning that these types of food “can cause heart disease.” In previous studies on men, Dr. Suarez found that men who lower their cholesterol levels with medication have increased rates of suicide and violent death, leading the researchers to theorize “that low cholesterol levels were causing mood disturbances.”
How many elderly statin-takers eke through their golden years feeling miserable and depressed, when they should be enjoying their grandchildren and looking back with pride on their accomplishments? But that is the new dogma–you may have a long life as long as it is experienced as a vale of tears.
Most doctors are convinced–and seek to convince their patients–that the benefits of statin drugs far outweigh the side effects. They can cite a number of studies in which statin use has lowered the number of coronary deaths compared to controls.
A Better Way
If statins work, they do so by reducing inflammation, not because they lower cholesterol. Statins block the production of mevalonate leading to inhibition of platelet clumping and reduction of inflammation in the artery walls. However, simple changes in the diet can achieve the same effect without also cutting off the body’s vital supply of cholesterol:
- Avoid trans fats, known to contribute to inflammation
- Avoid refined sugars, especially fructose, known to stimulate clumping of the blood platelets
- Take cod liver oil, an excellent dietary source of anti-inflammatory vitamin A, vitamin D and EPA
- Eat plenty of saturated fats, which encourage the production of anti-inflammatory prostaglandins
- Take evening primrose, borage or black currant oil, sources of GLA which the body uses to make anti-inflammatory prostaglandins
- Eat foods high in copper, especially liver; copper deficiency is associatied with clot formation and inflammation in the arteries
- Eat coconut oil and coconut products; coconut oil protects against bacteria and viruses that can lead to inflammation in the artery wall
- Avoid reduced-fat milks and powdered milk products (such as powdered whey); they contain oxidized cholesterol, shown to cause irritation of the artery wall
But as Dr. Ravnskov has pointed out in his book The Cholesterol Myths,31 the results of the major studies up to the year 2000–the 4S, WOSCOPS, CARE, AFCAPS and LIPID studies–generally showed only small differences and these differences were often statistically insignificant and independent of the amount of cholesterol lowering achieved. In two studies, EXCEL, and FACAPT/TexCAPS, more deaths occurred in the treatment group compared to controls. Dr. Ravnskov’s 1992 meta-analysis of 26 controlled cholesterol-lowering trials found an equal number of cardiovascular deaths in the treatment and control groups and a greater number of total deaths in the treatment groups.32 An analysis of all the big controlled trials reported before 2000 found that long-term use of statins for primary prevention of heart disase produced a 1 percent greater risk of death over 10 years compared to a placebo.33
Recently published studies do not provide any more justification for the current campaign to put as many people as possible on statin drugs.
Honolulu Heart Program (2001)
This report, part of an ongoing study, looked at cholesterol lowering in the elderly. Researchers compared changes in cholesterol concentrations over 20 years with all-cause mortality.34 To quote: “Our data accords with previous findings of increased mortality in elderly people with low serum cholesterol, and show that long-term persistence of low cholesterol concentration actually increases risk of death. Thus, the earlier that patients start to have lower cholesterol concentrations, the greater the risk of death. . . The most striking findings were related to changes in cholesterol between examination three (1971-74) and examination four (1991-93). There are few studies that have cholesterol concentrations from the same patients at both middle age and old age. Although our results lend support to previous findings that low serum cholesterol imparts a poor outlook when compared with higher concentrations of cholesterol in elderly people, our data also suggest that those individuals with a low serum cholesterol maintained over a 20-year period will have the worst outlook for all-cause mortality [emphasis ours].”
The MIRACL study looked at the effects of a high dose of Lipitor on 3086 patients in the hospital after angina or nonfatal MI and followed them for 16 weeks.35 According to the abstract: “For patients with acute coronary syndrome, lipid-lowering therapy with atorvastatin, 80 mg/day, reduced recurrent ischemic events in the first 16 weeks, mostly recurrent symptomatic ischemia requiring rehospitalization.” What the abstract did not mention was that there was no change in death rate compared to controls and no significant change in re-infarction rate or need for resuscitation from cardiac arrest. The only change was a significant drop in chest pain requiring rehospitalization.
ALLHAT (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial), the largest North American cholesterol-lowering trial ever and the largest trial in the world using Lipitor, showed mortality of the treatment group and controls after 3 or 6 years was identical.36 Researchers used data from more than 10,000 participants and followed them over a period of four years, comparing the use of a statin drug to “usual care,” namely maintaining proper body weight, no smoking, regular exercise, etc., in treating subjects with moderately high levels of LDL cholesterol. Of the 5170 subjects in the group that received statin drugs, 28 percent lowered their LDL cholesterol significantly. And of the 5185 usual-care subjects, about 11 percent had a similar drop in LDL. But both groups showed the same rates of death, heart attack and heart disease.
Heart Protection Study (2002)
Carried out at Oxford University,37 this study received widespread press coverage; researchers claimed “massive benefits” from cholesterol-lowering,38 leading one commentator to predict that statin drugs were “the new aspirin.”39 But as Dr. Ravnskov points out,40 the benefits were far from massive. Those who took simvastatin had an 87.1 percent survival rate after five years compared to an 85.4 percent survival rate for the controls and these results were independent of the amount of cholesterol lowering. The authors of the Heart Protection Study never published cumulative mortality data, even though they received many requests to do so and even though they received funding and carried out a study to look at cumulative data. According to the authors, providing year-by-year mortality data would be an “inappropriate” way of publishing their study results.41
PROSPER (Prospective Study of Pravastatin in the Elderly at Risk) studied the effect of pravastatin compared to placebo in two older populations of patients of which 56 percent were primary prevention cases (no past or symptomatic cardiovascular disease) and 44 percent were secondary prevention cases (past or symptomatic cardiovascular disease).42 Pravastatin did not reduce total myocardial infarction or total stroke in the primary prevention population but did so in the secondary. However, measures of overall health impact in the combined populations, total mortality and total serious adverse events were unchanged by pravastatin as compared to the placebo and those in the treatment group had increased cancer. In other words: not one life saved.
Japanese Lipid Intervention Trial was a 6-year study of 47,294 patients treated with the same dose of simvastatin.43 Patients were grouped by the amount of cholesterol lowering. Some patient had no reduction in LDL levels, some had a moderate fall in LDL and some had very large LDL reductions. The results: no correlation between the amount of LDL lowering and death rate at five years. Those with LDL cholesterol lower than 80 had a death rate of just over 3.5 at five years; those whose LDL was over 200 had a death rate of just over 3.5 at five years.
In a meta-analysis of 44 trials involving almost 10,000 patients, the death rate was identical at 1 percent of patients in each of the three groups–those taking atorvastatin (Lipitor), those taking other statins and those taking nothing.44 Furthermore, 65 percent of those on treatment versus 45 percent of the controls experienced an adverse event. Researchers claimed that the incidence of adverse effects was the same in all three groups, but 3 percent of the atorvastatin-treated patients and 4 percent of those receiving other statins withdrew due to treatment-associated adverse events, compared with 1 percent of patients on the placebo.
Statins and Plaque (2003)
A study published in the American Journal of Cardiology casts serious doubts on the commonly held belief that lowering your LDL-cholesterol, the so-called bad cholesterol, is the most effective way to reduced arterial plaque.45 Researchers at Beth Israel Medical Center in New York City examined the coronary plaque buildup in 182 subjects who took statin drugs to lower cholesterol levels. One group of subjects used the drug aggressively (more than 80 mg per day) while the balance of the subjects took less than 80 mg per day. Using electron beam tomography, the researchers measured plaque in all of the subjects before and after a study period of more than one year. The subjects were generally successful in lowering their cholesterol, but in the end there was no statistical difference in the two groups in the progression of arterial calcified plaque. On average, subjects in both groups showed a 9.2 percent increase in plaque buildup.
Statins and Women (2003)
No study has shown a significant reduction in mortality in women treated with statins. The University of British Columbia Therapeutics Initiative came to the same conclusion, with the finding that statins offer no benefit to women for prevention of heart disease.46 Yet in February of 2004, Circulation published an article in which more than 20 organizations endorsed cardiovascular disease prevention guidelines for women with several mentions of “preferably a statin.”47
ASCOT-LLA (Anglo-Scandinavian Cardiac Outcomes Trial–Lipid Lowering Arm) was designed to assess the benefits of atorvastatin (Lipitor) versus a placebo in patients who had high blood pressure with average or lower-than-average cholesterol concentrations and at least three other cardiovascular risk factors.48 The trial was originally planned for five years but was stopped after a median follow-up of 3.3 years because of a significant reduction in cardiac events. Lipitor did reduce total myocardial infarction and total stroke; however, total mortality was not significantly reduced. In fact, women were worse off with treatment. The trial report stated that total serious adverse events “did not differ between patients assigned atorvastatin or placebo,” but did not supply the actual numbers of serious events.
Cholesterol Levels in
Dialysis Patients (2004)
In a study of dialysis patients, those with higher cholesterol levels had lower mortality than those with low cholesterol.49 Yet the authors claimed that the “inverse association of total cholesterol level with mortality in dialysis patients is likely due to the cholesterol-lowering effect of systemic inflammation and malnutrition, not to a protective effect of high cholesterol concentrations.” Keeping an eye on further funding opportunities, the authors concluded: “These findings support treatment of hypercholesterolemia in this population.”
Late-Breaking Cholesterol News
Researchers at the Tulane University School of Medicine used electron beam tomography (EBT) to measure the progression of plaque buildup in heart-attack patients taking statin drugs. EBT is a very accurate way to measure occlusion from calcium in the arteries. Contrary to expectations, the researchers discovered that the progression of coronary artery calcium (CAC) was significantly greater in patients receiving statins compared with event-free subjects despite similar levels of LDL-lowering. Said the researchers: “Continued expansion of CAC may indicate failure of some patients to benefit from statin therapy and an increased risk of having cardiovascular events (Arterioscler Thromb Vasc Biol, April 1, 2004).
Doctors have discovered that injections of a certain substance can reverse heart disease in some patients. The therapy has helped reduce the amount of plaque in the arteries, thereby negating the need for angioplasty and open heart surgery. That substance is HDL-cholesterol (www.ivanhoe.com/newsalert, March 1, 2004).
The Melbourne Women’s Midlife Health Project measured cholesterol levels annually in a group of 326 women aged 52-63 years. During the eighth annual visit, subjects took a test that assessed memory. They found that higher serum concentrations of LDL-cholesterol and relatively recent increases in total cholesterol and LDL-cholesterol were associated with better memory in healthy middle-aged women (J Neurol Neurosurg Psychiatry 2003;74:1530-1535.)
PROVE-IT (PRavastatin Or AtorVastatin Evaluation and Infection Study),50 led by researchers at Harvard University Medical School, attracted immense media attention. “Study of Two Cholesterol Drugs Finds One Halts Heart Disease,” was the headline in the New York Times.51 In an editorial entitled “Extra-Low Cholesterol,” the paper predicted that “The findings could certainly presage a significant change in the way heart disease patients are treated. It should also start a careful evaluation of whether normally healthy people could benefit from a sharp drug-induced reduction in their cholesterol levels.”52
The Washington Post was even more effusive, with a headline “Striking Benefits Found in Ultra-Low Cholesterol.”53 “Heart patients who achieved ultra-low cholesterol levels in one study were 16 percent less likely to get sicker or to die than those who hit what are usually considered optimal levels. The findings should prompt doctors to give much higher doses of drugs known as statins to hundreds of thousands of patients who already have severe heart problems, experts said. In addition, it will probably encourage physicians to start giving the medications to millions of healthy people who are not yet on them, and to boost dosages for some of those already taking them to lower their cholesterol even more, they said.”
The study compared two statin drugs, Lipitor and Pravachol. Although Bristol Myers-Squibb (BMS), makers of Pravachol, sponsored the study, Lipitor (made by Pfizer) outperformed its rival Pravachol in lowering LDL. The “striking benefit” was a 22 percent rate of death or further adverse coronary events in the Lipitor patients compared to 26 percent in the Pravachol patients.
PROVE-IT investigators took 4162 patient who had been in the hospital following an MI or unstable angina. Half got Pravachol and half got Lipitor. Those taking Lipitor had the greatest reduction of LDL-cholesterol–LDL in the Pravachol group was 95, in the Lipitor group it was 62–a 32 percent greater reduction in LDL levels and a 16 percent reduction in all-cause mortality. But that 16 percent was a reduction in relative risk. As pointed out by Red Flags Daily columnist Dr. Malcolm Kendrick, the absolute reduction in the rate of the death rate of those taking Lipitor rather than Pravachol, was one percent, a decrease from 3.2 percent to 2.2 percent over 2 years.54 Or, to put it another way, a 0.5 percent absolute risk reduction per year–these were the figures that launched the massive campaign for cholesterol-lowering in people with no risk factors for heart disease, not even high cholesterol.
And the study was seriously flawed with what Kendrick calls “the two-variables conundrum.” “It is true that those with the greatest LDL lowering were protected against death. However, . . . those who were protected not only had a greater degree of LDL lowering, they were also on a different drug! which is rather important, yet seems to have been swept aside on a wave of hype. If you really want to prove that the more you lower the LDL level, the greater the protection, then you must use the same drug. This achieves the absolutely critical requirement of any scientific experiment, which is to remove all possible uncontrolled variables. . . As this study presently stands, because they used different drugs, anyone can make the case that the benefits seen in the patients on atorvastatin [Lipitor] had nothing to do with greater LDL lowering; they were purely due to the direct drug effects of atorvastatin.” Kendrick notes that the carefully constructed J-LIT study, published 2 years earlier, found no correlation whatsoever between the amount of LDL lowering and death rate. This study had ten times as many patients, lasted almost three times as long and used the same drug at the same dose in all patients. Not surprisingly, J-LIT attracted virtually no media attention.
PROVE-IT did not look at side effects but Dr. Andrew G. Bodnar, senior vice president for strategy and medical and external affairs at Bristol Meyer Squibb, makers of the losing statin, indicated that liver enzymes were elevated in 3.3 percent of the Lipitor group but only in 1.1 percent of the Pravachol group, noting that when liver enzyme levels rise, patients must be advised to stop taking the drug or reduce the dose.55 And withdrawal rates were very high: thirty-three percent of patients discontinued Pravachol and 30 percent discontinued Lipitor after two years due to adverse events or other reasons.56
In a similar study, carried out at the Cleveland Clinic, patients were given either Lipitor or Pravachol. Those receiving Lipitor achieved much lower LDL-cholesterol levels and a reversal in “the progression of coronary plaque aggregation.”57 Those who took Lipitor had plaque reduced by 0.4 percent over 18 months, based on intravascular ultrasound (not the more accurate tool of electron beam tomography); Dr. Eric Topol of the Cleveland Clinic claimed these decidedly unspectacular results “Herald a shake-up in the field of cardiovascular prevention.. . . the implications of this turning point–that is, of the new era of intensive statin therapy–are profound. Even today, only a fraction of the patients who should be treated with a statin are actually receiving such therapy. . . More than 200 million people worldwide meet the criteria for treatment, but fewer than 25 million take statins.”58 Not surprisingly, an article in The Wall Street Journal noted “Lipitor Prescriptions Surge in Wake of Big Study.”59
But as Dr. Ravnskov points out, the investigators looked at change in atheroma volume, not the change in lumen area, “a more important parameter because it determines the amount of blood that can be delivered to the myocardium. Change of atheroma volume cannot be translated to clinical events because adaptive mechansims try to maintain a normal lumen area during early atherogenesis.”60
With such paltry evidence of benefit, statin drugs hardly merit the hyperbole heaped upon them. Yet the industry maintains a full court press, urging their use for greater and greater numbers of people, not only for cholesterol lowering but also as treatment for other diseases–cancer, multiple sclerosis, osteoporosis, stroke, macular degeneration, arthritis and even mental disorders such as memory and learning problems, Alzheimers and dementia.61 New guidelines published by the American College of Physicians call for statin use by all people with diabetes older than 55 and for younger diabetes patients who have any other risk factor for heart disease, such as high blood pressure or a history of smoking.62 David A. Drachman, professor of neurology at the University of Massachusetts Medical School calls statins “Viagra for the brain.”63 Other medical writers have heralded the polypill, composed of a statin drug mixed with a blood pressure medication, aspirin and niacin, as a prevent-all that everyone can take. The industry is also seeking the right to sell statins over the counter.
Can honest assessment find any possible use for these dangerous drugs? Dr. Peter Langsjoen of Tyler, Texas, suggests that statin drugs are appropriate only as a treatment for cases of advanced Cholesterol Neurosis, created by the industry’s anti-cholesterol propaganda. If you are concerned about your cholesterol, a statin drug will relieve you of your worries.
The best advertising for statin drugs is free front-page coverage following gushy press releases. But not everyone reads the paper or goes in for regular medical exams, so statin manufacturers pay big money for creative ways to create new users. For example, a new health awareness group called the Boomer Coalition supported ABC’s Academy Awards telecast in March of 2004 with a 30-second spot flashing nostalgic images of celebrities lost to cardiovascular disease–actor James Coburn, baseball star Don Drysdale and comedian Redd Foxx. While the Boomer Coalition sounds like a grass roots group of health activists, it is actually a creation of Pfizer, manufacturers of Lipitor. “We’re always looking for creative ways to break through what we’ve found to be a lack of awareness and action,” says Michal Fishman, a Pfizer spokeswoman. “We’re always looking for what people really think and what’s going to make people take action,” adding that there is a stigma about seeking treatment and many people “wrongly assume that if they are physically fit, they aren’t at risk for heart disease.”64 The Boomer Coalition website allows visitors to “sign up and take responsibility for your heart health,” by providing a user name, age, email address and blood pressure and cholesterol level.
A television ad in Canada admonished viewers to “Ask your doctor about the Heart Protection Study from Oxford University.” The ad did not urge viewers to ask their doctors about EXCEL, ALLHAT, ASCOT, MIRACL or PROSPER, studies that showed no benefit–and the potential for great harm–from taking statin drugs.
Statin drugs are very expensive–a course of statins for a year costs between $900 and $1400. They constitute the mostly widely sold pharmaceutical drug, accounting for 6.5 percent of market share and 12.5 billion dollars in revenue for the industry. Your insurance company may pay most of that cost, but consumers always ultimately pay with higher insurance premiums. Payment for statin drugs poses a huge burden for Medicare, so much so that funds may not be available for truly lifesaving medical measures.
In the UK, according to the National Health Service, doctors wrote 31 million prescriptions for statins in 2003, up from 1 million in 1995 at a cost of 7 billion pounds–and that’s just in one tiny island.65 In the US, statins currently bring in $12.5 billion annually for the pharmaceutical industry. Sales of Lipitor, the number-one-selling statin, are projected to hit $10 billion in 2005.
Even if statin drugs do provide some benefit, the cost is very high. In the WOSCOP clinical trial where healthy people with high cholesterol were treated with statins, the five-year death rate for treated subjects was reduced by a mere 0.6 percent. As Dr. Ravnskov points out,66 to achieve that slight reduction about 165 healthy people had to be treated for five years to extend one life by five years. The cost for that one life comes to $1.2 million dollars. In the most optimistic calculations, the costs to save one year of life in patients with CHD is estimated at $10,000, and much more for healthy individuals. “This may not sound unreasonable,” says Dr. Ravnskov. “Isn’t a human life worth $10,000 or more?”
“The implication of such reasoning is that to add as many years as possible, more than half of mankind should take statin drugs every day from an early age to the end of life. It is easy to calculate that the costs for such treatment would consume most of any government’s health budget. And if money is spent to give statin treatment to all healthy people, what will remain for the care of those who really need it? Shouldn’t health care be given primarily to the sick and the crippled?”
Read the Fine Print
The picture in a recent ad for Lipitor implies that cholesterol-lowering is for everyone, even slim young women. However, in the fine print we learn that Lipitor “has not been shown to prevent heart disease or heart attacks”! If the makers of Lipitor need to provide this disclaimer, after millions of dollars invested in studies, why should anyone risk side effects by taking their drug?
About the Authors
Mary G. Enig, PhD is an expert of international renown in the field of lipid biochemistry. She has headed a number of studies on the content and effects of trans fatty acids in America and Israel, and has successfully challenged government assertions that dietary animal fat causes cancer and heart disease. Recent scientific and media attention on the possible adverse health effects of trans fatty acids has brought increased attention to her work. She is a licensed nutritionist, certified by the Certification Board for Nutrition Specialists, a qualified expert witness, nutrition consultant to individuals, industry and state and federal governments, contributing editor to a number of scientific publications, Fellow of the American College of Nutrition and President of the Maryland Nutritionists Association. She is the author of over 60 technical papers and presentations, as well as a popular lecturer. Dr. Enig is currently working on the exploratory development of an adjunct therapy for AIDS using complete medium chain saturated fatty acids from whole foods. She is Vice-President of the Weston A Price Foundation and Scientific Editor of Wise Traditions as well as the author of Know Your Fats: The Complete Primer for Understanding the Nutrition of Fats, Oils, and Cholesterol, Bethesda Press, May 2000. She is the mother of three healthy children brought up on whole foods including butter, cream, eggs and meat.
Sally Fallon is the author of Nourishing Traditions: The Cookbook that Challenges Politically Correct Nutrition and the Diet Dictocrats (with Mary G. Enig, PhD), a well-researched, thought-provoking guide to traditional foods with a startling message: Animal fats and cholesterol are not villains but vital factors in the diet, necessary for normal growth, proper function of the brain and nervous system, protection from disease and optimum energy levels. She joined forces with Enig again to write Eat Fat, Lose Fat, and has authored numerous articles on the subject of diet and health. The President of the Weston A. Price Foundation and founder of A Campaign for Real Milk, Sally is also a journalist, chef, nutrition researcher, homemaker, and community activist. Her four healthy children were raised on whole foods including butter, cream, eggs and meat.
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2. Eleanor Laise. The Lipitor Dilemma, Smart Money: The Wall Street Journal Magazine of Personal Business, November 2003.
3. Eleanor Laise. The Lipitor Dilemma, Smart Money: The Wall Street Journal Magazine of Personal Business, November 2003.
4. Beatrice A. Golomb, MD, PhD on Statin Drugs, March 7, 2002. www.coloradohealthsite.org/topics/interviews/golomb.html
5. Melissa Siig. Life After Lipitor: Is Pfizer product a quick fix or dangerous drug? Residents experience adverse reactions. Tahoe World, January 29, 2004.
6. Jamil S, Iqbal P. Heart 2004 Jan;90(1):e3.
7. Personal communication, Laura Cooper, May 1, 2003.
8. Sinzinger H, O’Grady J. Br J Clin Pharmacol. 2004 Apr;57(4):525-8.
9. Smith DJ and Olive KE. Southern Medical Journal 96(12):1265-1267, December 2003.
10. Gaist D and others. Neurology 2002 May 14;58(9):1321-2.
11. Statins and the Risk of Polyneuropathy. http://coloradohealthsite.org/CHNReports/statins_polyneuropathy.html
12. The Struggles of Older Drivers, letter by Elizabeth Scherdt. Washington Post, June 21, 2003.
13. Langsjoen PH. The clinical use of HMG Co-A reductase inhibitors (statins) and the associated depletion of the essential co-factor coenzyme Q10: a review of pertinent human and animal data. http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-02-Exhibit_A-vol1.pdf
14. Eleanor Laise. The Lipitor Dilemma, Smart Money: The Wall Street Journal Magazine of Personal Business, November 2003.
15. Langsjoen PH. The clinical use of HMG Co-A reductase inhibitors (statins) and the associated depletion of the essential co-factor coenzyme Q10: a review of pertinent human and animal data. http://www.fda.gov/ohrms/dockets/dailys/02/May02/052902/02p-0244-cp00001-02-Exhibit_A-vol1.pdf
16. Clark AL and others. J Am Coll Cardiol 2003;42:1933-1943.
17. Personal communication, Jason DuPont, MD, July 7, 2003
18. Sandra G Boodman. Statins’ Nerve Problems. Washington Post, September 3, 2002.
19. Eleanor Laise. The Lipitor Dilemma, Smart Money: The Wall Street Journal Magazine of Personal Business, November 2003,
20. King, DS. Pharmacotherapy 25(12):1663-7, Dec, 2003.
21. Muldoon MF and others. Am J Med 2000 May;108(7):538-46.
22. Email communication, Beatrice Golomb, July 10, 2003.
23. Duane Graveline, MD. Lipitor: Thief of Memory, 2004, www.buybooksontheweb.com.
24. Lopena OF. Pharm D, Pfizer, Inc., written communication, 2002. Quoted in an email communication from Duane Graveline, email@example.com
25. Newman TB, Hulley SB. JAMA 1996;27:55-60
26. Sacks FM and others. N Eng J Med 1996;385;1001-1009.
27. Heart Protection Study Collaborative Group. Lancet 2002;360:7-22.
28. Leung BP and others. J Immunol. Feb 2003 170(3);1524-30; Palinski W. Nature Medicine Dec 2000 6;1311-1312.
29. J Pharm Technol 2003;19:283-286.
30. Low Cholesterol Linked to Depression. BBC Online Network, May 25,1999.
31. Uffe Ravnskov, MD, PhD. The Cholesterol Myths. NewTrends Publishing, 2000.
32. Ravnskov U. BMJ. 1992;305:15-19.
33. Jackson PR. Br J Clin Pharmacol 2001;52:439-46.
34. Schatz IJ and others. Lancet 2001 Aug 4;358:351-355.
35. Schwartz GG and others. J Am Med Assoc. 2001;285:1711-8.
36. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. JAMA 2002;288:2998-3007.
37. Heart Protection Study Collaborative Group. Lancet 2002;360:7-22.
38. Medical Research Council/British Heart Foundation Heart Protection Study.Press release. Life-saver: World’s largest cholesterol-lowering trial reveals massive benefits for high-risk patients. Available at www.ctsu.ox.ac.uk/~hps/pr.shtml.
39. Kmietowicz A. BMJ 2001;323:1145
40. Ravnskov U. BMJ 2002;324:789
41. Email communication, Eddie Vos, February 13, 2004 and posted at www.health-heart.org/comments.htm#PetoCollins.
42. Shepherd J and others. Lancet 2002;360:1623-1630.
43. Matsuzaki M and others. Circ J. 2002 Dec;66(12):1087-95.
44. Hecht HS, Harmon SM. Am J Cardiol 2003; 92:670-676
45. Hecht HS and others. Am J Cardiol 2003;92:334-336
46. Jenkins AJ. BMJ 2003 Oct 18;327(7420):933.
47. Circulation, 2004 Feb 17;109(6):714-21.
48. Sever PS and others. Lancet 2003;361:1149-1158.
49. Liu Y and others. JAMA 2004;291:451-459.
50. Cannon CP and others. N Engl J Med 2004 Apr 8;350(15):1495-504. Epub 2004 Mar 08.
51. Gina Kolata. Study of Two Cholesterol Drugs Finds One Halts Heart Disease. The New York Times, November 13, 2003.
52. Extra-Low Cholesterol, The New York Times, March 10, 2003
53. Rob Stein. Striking Benefits Found in Ultra-Low Cholesterol, The Washington Post, March 9, 2004
54. Dr. Malcolm Kendrick. PROVE IT- PROVE WHAT? http://www.redflagsweekly.com/applications/ui/login.php?Next=/kendrick/2004_mar10.php&e=4
55. Health Sciences Institute e-alert, www.hsibaltimore.com, March 11, 2004
56. Email communication, Joel Kauffman, April 15, 2004.
57. Nissen SE and others. JAMA 2004 Mar 3;291(9):1071-80.
58. Dr. Malcolm Kendrick. PROVE IT- PROVE WHAT? http://www.redflagsweekly.com/applications/ui/login.php?Next=/kendrick/2004_mar10.php&e=4
59. Scott Hensley. The Statin Dilemma: How Sluggish Sales Hurt Merck, Pfizer. The Wall Street Journal, July 25, 2003.
60. Ravnskov, U. Unpublished letter. firstname.lastname@example.org .
61. Cholesterol–And Beyond: Statin Drugs Have Cut Heart Disease. Now They Show Promise Against Alzheimer’s, Multiple Sclerosis & Osteoporosis. Newsweek, July 14. 2003.
62. John O’Neil. Treatments: Statins and Diabetes: New Advice. New York Times, April 20, 2004.
63. Peter Jaret. Statins’ Burst of Benefits. Los Angeles Times, July 2. 2003.
64. Behind the ‘Boomer Coalition,’ A Heart Message from Pfizer, Wall Street Journal, March 10, 2004
65. Paul J. Fallon, personal communication, March, 2004.
66. Uffe Ravnskov, MD, PhD. The Cholesterol Myths. NewTrends Publishing, 2000, pp 208-210.
Natural Solutions for Neurotransmitter Disorders
Key to Depression, Anxiety and
Other Neurotransmitter-Related Disorders
A deficiency of neurotransmitters (also called “NT’s or “brain hormones”) causes or contributes to a wide variety
of diseases including depression, anxiety, and
overweight / obesity.
- Attention Deficit Disorder (ADD / ADHD)
- Adrenal Fatigue / Burnout
- Addictions / addiction withdrawal
- Aggression (inappropriate)
- Alzheimer’s Disease
- Anger (inappropriate)
- Chronic Fatigue Syndrome
- Cognitive Impairment / Mild Cognitive Impairment
- Crohn’s Disease
- Eating Disorders
- Hormone Dysfunction
- Insomnia / Sleep Disorders
- Irritable Bowel Syndrome (IBS)
- Menopausal Symptoms
- Migraine Headaches
- Mood Disorder (anger, anxiety, depression)
- Nocturnal Myoclonus
- Obesity / Overweight / Eating Disorders
- Obsessive-Compulsive Disorder (OCD)
- Pain (chronic)
- Panic Attacks
- Pre-Menstrual Syndrome (PMS)
- Psychosis / Psychotic Disorder
- Restless Legs Syndrome
- Tension Headaches
- Tempero-Mandibular Joint Dysfunction (TMJ)
I.) Decreased production of neurotransmitters due to:
- A deficiency of NT precursors (not enough “raw materials” in the body to correctly manufacture NT’s)
- Inborn errors of metabolism (an individual may have a genetic need for more of the “raw materials” used to build neurotransmitters)
- Toxic damage to portions of the brain or peripheral nervous system that produce NT’s
II.) Increased need for neurotransmitters due to:
Toxic damage to or destruction of the nerve cells the respond to NT input
Excess degradation of existing NeuroTransmitters due to reuptake inhibiting drugs or recreational drugs
Better Cholesterol Management with Vitamins and Herbs
Your Cholesterol Questions Answered
What can be done if you’ve been told that you have “high cholesterol?” I’ve been getting questions “in spades” this week, so it’s time for a cholesterol management update! Like Lennie who wrote “I would like to know what supplements you recommend to lower LDL besides diet. I do not want to take statins. Thanks for your news letter I do read it. Blessings, Lennie.”
Perhaps your conventional doctor found your cholesterol levels to be “high” (and there are differing opinions on what “too high” really is, because cholesterol is only ONE of a number of heart risk factors). He or she has probably advised you to start taking a “statin” drug. You will likely be sent off with a prescription for the statin-de-jour along with a recommendation to “eat less cholesterol and cut down on fats.” If you do a little research, you will discover that statin drugs have some worrisome side-effects, including elevated liver enzymes (indicating liver distress) and rhabdomyelosis (muscle damage; NOTE: the heart is a muscle). You might also see that there are dozens, maybe even hundreds, of natural remedies, all claiming to be “the best” for safely lowering cholesterol levels. We (Dr. Myatt and Nurse Mark) chuckle when we get questions from Wellness Club members asking if we have heard about the latest and greatest pill or potion or “cure” – we’ve heard ’em all and then some!
While statin drugs are being marketed as the next best drug since antibiotics, the dangers and expense of these drugs are rarely mentioned. All the while, well-proven natural remedies exist to reduce LDL cholesterol levels, total cholesterol levels, triglycerides and various other heart risk factors. Along with proven natural remedies come another half-dozen substances that are seen to be helpful but are not as well researched. And of course, as with all other natural remedies, there are an entire array of poorly-researched, unproven remedies that rely on anecdotal “patient success stories” in their glowingly inflated sales pitches. Beware – these “also rans” aren’t known to perform like proven remedies and may leave you sorely disappointed with the results.
The Big Three Remedies for High Cholesterol
1.) Niacin The most well-studied natural agent for cholesterol improvement is niacin, a B complex vitamin. Niacin’s effect on cholesterol has been known since the 1950’s when it was found to be a highly effective cholesterol lowering agent. Studies have shown that niacin not only lowers LDL cholesterol, but also Lp(a), triglyceride, and fibrinogen (a blood protein that causes clot formation) levels, while it simultaneously raises beneficial HDL cholesterol levels. The Coronary Drug Project, an intensive and extensive evaluation of cholesterol-lowering drugs demonstrated that niacin was the only cholesterol-lowering agent that actually reduced overall mortality. Its effects were also found to be long lived, protecting patients in the study years after they had stopped taking it. Here is how niacin compares to cholesterol-lowering drugs:
Drug Class LDL HDL TG BAR’s
(Bile Acid Resins) ▼(decreased)
3-5% +/- Niacin ▼(decreased)
20-50% Statins ▼(decreased)
7-30% Fibric Acids ▼(decreased)
20-50% Cholesterol Absorption Inhibitors ▼(decreased)
20% +/- ▼(decreased)
Note that although statins can have a bigger impact on LDL cholesterol levels, niacin is more effective at lowering tryglycerides and raising HDL (the good cholesterol). Also be aware that cholesterol levels can be too low. Cholesterol levels under 140 are associated with an increased risk of strokes.
Like any substance, high-dose niacin is not without cautions. It’s side effects are well known, the most common being a “niacin flush” – an uncomfortable flushing or hot feeling experienced by some people after taking standard niacin. Niacin can be toxic to the liver when taken in a “time release” form that was developed to avoid the problem of the “niacin flush” that made some patients reluctant to use it. Niacin can alter blood sugar control and so should be used under medical supervision in people with diabetes. It is also important to monitor both cholesterol levels and liver enzyme levels every three months or so while using niacin, as with a statin drug. Dr. Myatt recommends a form of niacin called inositol hexaniacinate, a No-Flush Niacin that is very well tolerated.
If niacin is so great, why don’t the drug companies sell it, and why doesn’t my doctor tell me to take it, you ask? Well, though the studies strongly supports the use of niacin, it has also been victim of a lot of misinformation – your doctor may be ill-informed about it’s benefits, while he or she has certainly been told all about the “benefits” of statins. Niacin is a widely available “generic” substance, meaning it cannot be patented, and the drug companies do not stand to make from it the massive profits that the other cholesterol-lowering drugs have generated for them.
As a result, one rarely sees niacin advertised in the way that the expensive statin drugs are. Still, niacin should be considered as the first choice in a cholesterol-lowering treatment.
NOTE: If your doctor DOES prescribe niacin, it will most likely be the pharmaceutical “timed release” version. Studies show that timed release niacin is toxic to the liver and DOES NOT have better benefit than NON timed-release formulas. DO NOT TAKE timed-release niacin for high cholesterol!
2.) Red Rice Yeast is next in importance. This substance is actually the result of a fungus that grows on white rice, turning it a red color. It has been known for centuries, and used as a colorant in oriental cuisine, and to make a form of red sake (rice wine). The active component in Red Rice Yeast is a compound called mevinolin, which is identical to the prescription drug, lovastatin. The drug companies created lovastatin in the laboratory in 1987 also using a fungus, Aspergillus terreus. The active ingredient in Red Rice Yeast was discovered and isolated a decade earlier. Red Rice Yeast has been proven to be just as effective as the modern statin drugs at lowering LDL cholesterol. Taken in high doses, it can have some of the same risks as the modern statin drugs – namely a risk of liver damage and also of rhabdomyolysis, a condition that includes muscle deterioration.
Anyone taking this or any statin drug should have a baseline liver enzyme check and have their liver enzymes checked at three months into treatment. But risks are small (about 2%). The good news is that it is thought that there is a synergistic effect obtained from other related compounds in Red Rice Yeast which allows much smaller doses to be effective. A typical dose of a statin drug would be in the range of 20-80mg/day while a typical dose of Red Rice Yeast would be about 2.5-10mg/day. Neither Red Rice Yeast nor statin drugs should be taken with grapefruit juice, as this can cause a dangerous buildup of the statin compounds in the body.
Due to drug company pressure on the FDA, many Red Rice Yeast products have been taken off the market because they contain— guess what?— the active ingredient for lowering cholesterol! The FDA said that this made them a drug. Statin drugs are now a 10+ billion dollar a year business for the drug companies (statins are the biggest selling drug of all time), and I believe the they do not want any competition from a natural remedy, especially one that works successfully, has far less negative side effects, and can be taken for about 1/4 the monthly cost of the drug versions. Although the FDA has waffled back and forth about Red Rice Yeast, it is still currently available and should be added to your cholesterol-lowering program if niacin alone fails to help within 8 weeks OR if your total cholesterol is above 240 or your hs-CRP is elevated.
3.) CoQ10 is a naturally-occurring antioxidant produced in the human body. It is vitally involved in energy production. CoQ10 functions as an “energizer” to mitochondria, the body’s energy producing units. Muscles, and the heart in particular, have high requirements for CoQ10. Although CoQ10 is produced by the body, age, nutrient deficiencies, disease and some medications can lower the body’s CoQ10 levels. Cholesterol-lowering drugs (statins) are known to deplete CoQ10. (The original patent-holders of statins wanted to add CoQ10 to the drug because of this known depletion; the FDA denied their request). Everyone taking a statin drug should also be taking CoQ10. In fact, because CoQ10 is necessary for normal heart function, I strongly recommend it’s use for any type of heart disease, including coronary artery disease, arrhythmia, high blood pressure and as part of a cholesterol-lowering program.
Other Proven Cholesterol-Lowering Agents
Garlic is another well-known cholesterol-lowering agent is with a wide spectrum of additional beneficial effects including blood pressure regulation, effective antibiotic scope and potent immune stimulant. Here however we are interested in garlic’s proven ability to lower LDL cholesterol when taken in appropriate doses of preparations that contains the the ingredient allicin. Allicin is the product of the substance alliin and the enzyme alliinase, and is fragile, dissipating quickly and easily during processing. A minimum therapeutic intake of allicin is considered to be about 4000 mcg. That is the equivalent to about one to four cloves of whole fresh garlic (depending on the size of the clove.) It is true that simply eating garlic (and it’s cousin onion) can have an excellent effect for lowering LDL cholesterol, blood pressure, and blood fibrinogen levels. Please remember that this effect is lost when garlic or onion is cooked, as cooking quickly destroys the active ingredient allicin.
Anyone looking to buy garlic supplements should be aware of the German Commission E, a panel of experts which sets standards for dosage requirements to allow for therapeutic claims. Check the label to make sure the supplement you are considering meets their standards for strength and purity.
Vitamin C has a well-studied positive effect on lowering total cholesterol and triglyceride levels while raising beneficial HDL levels. Vitamin C supplementation is valuable for many other reasons – it is an powerful antioxidant, and an immune enhancer. If you are considering using higher doses of vitamin C, use buffered vitamin C to avoid stomach upset. Also remember that Dr. Myatt’s Maxi-Multi contains 1,200 mg of this important vitamin when taken in the recommended daily dose.
Fiber has a time-honored place in any cholesterol-lowering regimen. High intakes of soluble fiber have been shown to lower both overall and LDL cholesterol levels. Unfortunately, such high intakes of fiber can cause gastrointestinal upset in many people, and this causes them to not take effective doses. Psyllium and oat bran are two of the most-studied, and are easily available to add to the diet. You should NOT take psyllium at the same time you take the prescription drugs carbamazepine, lithium, digitalis or nitrofurantoin because psyllium will decrease their absorption and effectiveness. Another form of fiber that is demonstrating great promise as a cholesterol-lowering aid is chitosan which is a substance made from the shells of shellfish. Chitosan has the effect of binding fat and cholesterol in the digestive tract. It is so effective at this that it will absorb as much as seven to eight times it’s own weight in fat and bile which are then passed through the bowel and excreted. Because of it’s fat-binding ability, chitosan is valuable as a weight loss aid as well as a cholesterol-normalizing agent. There are just a couple of caveats regarding chitosan: first, like any other fiber, chitosan can interfere with the absorption of certain nutrients and trace minerals. These should be taken at times other than when chitosan when is taken. Secondly, because chitosan is derived from the exoskeletons (shells) of shellfish, people with seafood allergies should use caution.
The above list is the top half-dozen, proven, tested, effective cholesterol-lowering supplements and agents. They are not the only things in our armamentarium (that’s a medical word for “bag of tricks”!) though. Some of the “lesser lights” are not as well proven, or not as specifically effective at lowering cholesterol, but they may still be very valuable as a part of a coordinated cholesterol-lowering and health improving plan.
More Cholesterol-Lowering Substances
Artichoke has been studied since the 1930’s and found to have excellent effects on both atherosclerotic plaque and cholesterol and LDL levels. It is also highly protective, and may even be regenerative to the liver. It also possesses antioxidant properties. It is a valuable addition to a person’s daily supplementation. Dr. Myatt makes this available in combination with Milk Thistle which is a potent liver protector with regenerative properties and a powerful antioxidant and Turmeric which is a marvelous anti-inflammatory, antioxidant, liver-protective (on a par with milk thistle), anti-tumorgenic herb that also helps maintain normal blood viscosity. My Milk Thistle Plus+ Formula combines all three of these herbs for a powerful liver-enhancing effect.
Turmeric has been shown in a number of studies to have cholesterol-lowering effects of it’s own. This, in addition to it’s other benefits as described above make it a “must do” in any daily supplementation program. Turmeric also inhibits platelet aggregation (med-speak for blood clotting) and serves as a natural cox-2 inhibitor like the prescription drug Vioxx.
Gugulipid is an ancient remedy that is being “rediscovered” by the western medical establishment. Gugulipid is made from the resin of the commiphora mukul tree of north central India and has been used for thousands of years to alleviate problems associated with obesity, acne, viral infections, and other ailments. It has also been shown in some limited but significant studies to reduce cholesterol and LDL levels and increase HDL levels within three to four weeks. It is certainly worth considering adding this to a cholesterol-lowering regimen.
Green Tea has also been the subject of some promising and even exciting research. Green tea serves as a potent antioxidant, preventing the oxidation of LDL in the arteries. The cholesterol-lowering effects of Green tea have been shown in numerous animal and human studies. Green tea catechins act to limit the rise in blood cholesterol according to a 1996 Japanese study. Further, Green tea has been shown to elevate HDL, and serves as a natural ACE inhibitor, lowering blood pressure. These benefits can be obtained by drinking up to 10 cups of Green tea daily, or taking one to two capsules of Green tea extract daily.
Fish Oil has been shown to reduce high levels of triglycerides by an average of 35%. It does not appear to reduce cholesterol to that extent, but it does offer benefits when as part of an integrated therapy program. Scientific studies have demonstrated that alpha-linolenic acid (from flax or perilla oil) reduces the incidence of atherosclerosis, stroke, and second heart attacks. One study showed a 70% reduction in second heart attacks in those consuming this type of fatty acid.
Vitamin E protects us from more than 80 diseases and illnesses, including protecting us from the inhibiting the effects of oxidation of LDL and the development of atherosclerotic disease. Studies have also shown it to be effective as some hypocholesterolemic (cholesterol-lowering) drugs. Anyone considering adding vitamin E to their regimen should also add Selenium which works with vitamin E to prevent LDL oxidation. Both of these nutrients are found in Dr. Myatt’s Maxi-Multi.
Policosanol refers to a group of eight solid alcohols derived from sugar cane wax. Octacosanol is the major constituent of policosanol and proponents of this substance claim that Octacosanol is remarkably safe and effective at reducing cholesterol levels, and at reducing platelet aggregation. Current supplies are from Cuba and, in my opinion, too expensive. As the price comes down and the research some up, this may prove to be a worthy cholesterol-lowering agent. (The research would have to be VAST to surpass niacin, however).
Finally, Soy has been shown to confer numerous benefits through it’s isoflavones – genistein, daidzein, and glycitein. According to a study completed in 1997, “Potential mechanisms by which soy isoflavones might prevent atherosclerosis include a beneficial effect on plasma lipid concentrations, antioxidant effects, antiproliferative and antimigratory effects on smooth muscle cells, effects on thrombus formation, and maintenance of normal vascular reactivity.” Bottom line: if you want to reduce your risk of heart disease and elevated cholesterol levels, it is worth adding soy to your diet.
Unproven Cholesterol “Cures”
We’ve talked about the proven first line remedies and the second line “helpfuls,” now let’s talk about some substances that have been touted without proof to back them up.
Coral Calcium – promoted as the cure for every thing from cancer to high cholesterol to bad breath to spiritual weakness. Many of it’s top promoters are facing criminal prosecution. Avoid it. Not only does coral calcium often contain high lead levels, it is destructive to the coral reefs where it is derived. Calcium alone is not a proven cholesterol-lowering remedy; neither is coral calcium. If you need additional calcium/magnesium/bone nutrients, consider taking Cal-Mag Amino.
Various teas have been touted as total cholesterol cures, no doubt riding on the coattails of accepted Green Tea studies. Don’t believe them – Green Tea is an important part of a cholesterol-control program, but teas are not the whole answer!
Cinnamon capsules have recently been promoted as a cholesterol-reducing agent. We are not aware of any solid studies to support this. Cinnamon does seem to have a beneficial effect on blood sugar levels of type II diabetics though. The capsules seem a bit expensive, when you can simply add this spice to your food and beverages – try it in tea!
Vinegar, and most especially apple cider vinegar, have also enjoyed some popularity as folk remedies for high cholesterol. Again, there is no scientific evidence of beneficial effect – though “anecdotal evidence” of the “my best friend’s great aunt’s late husband used it every day ’till he died” variety is plentiful…
Beyond Supplements and Drugs: Live a “Good Cholesterol Lifestyle”
No cholesterol-lowering program would be complete without a discussion of diet. Instead of dire warnings and restrictive regimes that drastically limit fat intake, Dr. Myatt puts her patients on The Super Fast Diet for cholesterol control. Her patients find this to be a rich, balanced, satisfying diet, and they are pleasantly surprised to find that not only do their cholesterol levels normalize in short order, but so does their weight. This nutrient-rich diet has people feeling better, looking better, and performing better, and their lab results are the proof of it’s effectiveness.
Your Personal Cholesterol-Lowering Protocol
For more information and dosage recommendations for natural cholesterol lowering remedies, please visit The Wellness Club website here: High Cholesterol Protocol
High cholesterol is a correctable dietary problem, not a statin drug deficiency! You can improve your cardiovascular risk far better by correcting underlying problems than by taking a liver-function-blocking drug. Why settle for a Band-Aid when a CURE is available?!