Berberine 500mg 60 capsules


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SKU: N361 Category:


Powerful effects on blood sugar, cholesterol, heart disease and cancer

Berberine is an alkaloid derived from various plants including Goldenseal (Hydrastis canadensis), Oregon grape (Berberis aquifolium), Barberry (Berberis vulgaris), Chinese Goldenthread (Coptis) and other plants. It has a bright yellow color.

Same potency, now in ONE capsule instead of two!
Previous formula: 120 caps per bottle, 2 caps = 500mg (60 doses per bottle)
Now: 60 caps per bottle, 1 cap = 500mg (60 doses per bottle)

Actions of Berberine:

Broad-spectrum anti-microbial: (1-6, 60)
Berberine has been found to be an effective against:

  • Chlamydia
  • Candida (multiple species)
  • E. coli
  • Salmonella typhi
  • Entamoeba histolytica
  • Staphylococcus aureus
  • Streptococcus sanguis
  • Pseudomonas aeruginosa
  • Helicobacter pylori
  • other Gram-positive bacteria and fungi
  • Some studies suggest that goldenseal may also be effective against viruses, fungi, protozoans, helminths (worms) and MRSA (methicillin-resistant Staphylococcus

Blood sugar regulation / diabetes type II. Some studies have shown that berberine lowers blood sugar as effectively as the diabetes drug metformin. (7-18)

Cholesterol-lowering effects. Studies show lipid-lowering effects on total cholesterol, triglyceride and LDL cholesterol. (19-26)

Cardic effects. Berbeine has been found to have anti-arrhythmic effects and may also be useful for CHF (congestive heart failure). (27-34)

Anti-cancer effects. Berberine has been found to have anti-neoplastic effects against a wide variety of cancer cell types including brain, bladder, breast, bone, colon, liver, lung, prostate, skin cancer and leukemia. (35-59)

Learn More about Berberine in our HealthBeat News article:
The “Swiss Army Knife” Of Supplements

Berberine 500 mg of Berberine per each capsules.

Suggested Use As a dietary supplement:

For antimicrobial effect: Take one capsule two times daily for up to fourteen (14) days with water at mealtimes. Not to be taken by pregnant or lactating women or children under 12 years old.

For blood sugar regulation: one capsule, 3 times daily with meals.

N361 – Berberine 500mg – 60 vegetarian caps – $34.97

Product description: Berberine 500mg 60 vegetarian caps

Ingredients per capsule:
Berberine HCL 500 mg (Extracted from Berberis Aristata, root)
Calcium (as calcium carbonate) 35mg

Other ingredients: Vegetarian capsule (hydroxypropyl methylcellulose and water) and silicone dioxide.

Capsule: Vegetable source from cellulose, preservative free.

Hypoallergenic: Contains NO yeast, wheat, gluten, soy protein, milk/dairy, corn, sodium, sugar, starch, artificial coloring, preservatives, or flavoring.

100% Vegetarian Formula

Bottle contains both a desiccant and an anti-oxidant packet to protect the contents from degradation due to moisture and oxidation


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23.)  Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z, Si S, Pan H, Wang S, Wu J,  Wang Y, Li Z, Liu J, Jiang JD. Berberine is a novel cholesterol-lowering drug working through a  unique mechanism distinct from statins. Nat Med. 2004 Dec;10(12):1344-51. Epub 2004 Nov 7.
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Combination of simvastatin with berberine improves the lipid-lowering efficacy. Metabolism. 2008  Aug;57(8):1029-37.
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36.) Choi MS, Oh JH, Kim SM, Jung HY, Yoo HS, Lee YM, Moon DC, Han SB, Hong JT. Berberine  inhibits p53-dependent cell growth through induction of apoptosis of prostate cancer cells. Int J Oncol.  2009 May;34(5):1221-30.
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39.) Hamsa TP, Kuttan G. Berberine Inhibits Pulmonary Metastasis through Down-regulation of MMP in Metastatic B16F-10 Melanoma Cells. Phytother Res. 2011 Sep 26. doi: 10.1002/ptr.3586. [Epub ahead of print]
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41.) Hsu WH, Hsieh YS, Kuo HC, Teng CY, Huang HI, Wang CJ, Yang SF, Liou YS, Kuo WH.
Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL. Arch Toxicol. 2007 Oct;81(10):719-28. Epub 2007 Aug 3.
42.) Hwang JM, Kuo HC, Tseng TH, Liu JY, Chu CY. Berberine induces apoptosis through a  mitochondria/caspases pathway in human hepatoma cells. Arch Toxicol. 2006 Feb;80(2):62-73. Epub  2005 Sep 28.
43.) James MA, Fu H, Liu Y, Chen DR, You M. Dietary administration of berberine or Phellodendron amurense extract inhibits cell cycle progression and lung tumorigenesis. Mol Carcinog. 2011 Jan;50(1):1-7.
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45.) Kim S, Han J, Kim NY, Lee SK, Cho DH, Choi MY, Kim JS, Kim JH, Choe JH, Nam SJ, Lee  JE.Effect of berberine on p53 expression by TPA in breast cancer cells. Oncol Rep. 2012  Jan;27(1):210-5. doi: 10.3892/or.2011.1480. Epub 2011 Sep 29.
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49.) Liu B, Wang G, Yang J, Pan X, Yang Z, Zang L. Berberine inhibits human hepatoma cell invasion  without cytotoxicity in healthy hepatocytes. PLoS One. 2011;6(6):e21416. Epub 2011 Jun 24.
50.) Liu Z, Liu Q, Xu B, Wu J, Guo C, Zhu F, Yang Q, Gao G, Gong Y, Shao C. Berberine induces p53-dependent cell cycle arrest and apoptosis of human osteosarcoma cells by inflicting DNA damage. Mutat Res. 2009 Mar 9;662(1-2):75-83. Epub 2008 Dec 31.
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52.) Mantena SK, Sharma SD, Katiyar SK. Berberine inhibits growth, induces G1 arrest and apoptosis  in human epidermoid carcinoma A431 cells by regulating Cdki-Cdk-cyclin cascade, disruption of  mitochondrial membrane potential and cleavage of caspase 3 and PARP. Carcinogenesis. 2006 Oct;  27(10):2018-27. Epub 2006 Apr 18.
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