The Only Cholesterol-Lowering Agent Proven to Reduce Mortality*
Niacin, a member of the B complex vitamin family, is the only “drug” proven to reduce mortality from elevated cholesterol levels. The Coronary Drug Project, an extensive study of cholesterol-lowering drugs, found that niacin was the only “drug” that actually reduced mortality. (Niacin is a “B” vitamin but was tested head-to-head with drugs in the study). Follow-up studies showed that the niacin-treated group had an 11% lower death rate years after niacin therapy was discontinued, but the cholesterol-lowering drug group had an increased death rate. (Example: the Clofibrate group had a 36% higher death rate).(1)
Niacin compares favorably to the “statin” drugs but with an overall better safety profile. Conclusion of most researchers: niacin should be the first “drug” of choice for treating high cholesterol.
Our “No-Flush” inositol hexanicotinate form avoids the uncomfortable but harmless “flush” that can be experienced with high dose niacin therapy.
CAUTION with Prescription “timed release” niacin: Niacin is an inexpensive and proven help for high cholesterol. In typical Big Pharma fashion, this simple vitamin has been made into a “drug.” In order to do this, the drug is sold as a time-released niacin. The problem? Time-released niacin can cause liver toxicity and, rarely, liver failure.(2-6) This effect has not been seen with regular and no-flush “non drug” varieties of niacin.
Be sure to tell your doctor that you wish to use, or are using, niacin therapy. As with other cholesterol-lowering drug therapy, liver enzymes should be monitored every three months for the first six months of therapy.
Dr. Myatt’s Note: In 21 years of medical practice, I have not seen a single case of elevated liver enzymes caused by no-flush niacin.
NO-FLUSH NIACIN (Inositol Hexanicotinate)
Suggested dose: 1 cap, 3 times per day for two weeks, then increase to 2 caps, 3 times per day thereafter. Take with meals.
Each (one) capsule contains:
Niacin (as inositol hexanicotinate) …………………. 400 mg
Inositol (as inositol hexanicotinate)…………………..100 mg
Product # 155 (100 Capsules) $21.95
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1.) Fifteen Year Mortality in Coronary Drug Project Patients: Long-Term Benefit with Niacin,” J Am Coll Cardiol 8 (1986):1245-55.
2. McKenney JM, Proctor JD, Harris S, Chinchili VM. A comparison of the efficacy and toxic effects of sustained—vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672–7.
3. Knopp RH, Ginsberg J, Albers JJ, et al. Contrasting effects of unmodified and time-release forms of niacin on lipoproteins in hyperlipidemic subjects: clues to mechanism of action of niacin. Metabolism 1985;34:642–50.
4. Gray DR, Morgan T, Chretien SD, Kashyap ML. Efficacy and safety of controlled-release niacin in dyslipoproteinemic veterans. Ann Intern Med 1994;121:252–8.
5. Rader JI, Calvert RJ, Hathcock JN. Hepatic toxicity of unmodified and time-release preparations of niacin. Am J Med 1992;92:77–81 [Review].
6. Knopp RH. Niacin and hepatic failure. Ann Intern Med 1989;111:769 [letter].