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Phosphatidyl Serine

Improve Brain-Cell Communication

Phosphatidyl serine (PS), the major phospholipid in the brain, is responsible for normal membrane fluidity and integrity of brain cells. The functions of Phosphatidyl serine allow brain cells to communicate efficiently with each other.

The body manufactures Phosphatidyl serine. Lowered levels of Phosphatidyl serine are seen in aging in association with impaired mental function and depression in the elderly. Supplemental sources of Phosphatidyl serine include fish, green leafy vegetables, soybeans and rice.

Eleven double-blind studies have verified the effectiveness of Phosphatidyl serine, with significant improvements seen in:

  • mental performance
  • behavior
  • mood
  • age-related cognitive decline

Phosphatidyl serine has also been shown to lower elevated ACTH and cortisol levels and may therefore be effective in cases of excess adrenal function.

Suggested dose: 1 cap (100 mg PS), 3 times per day. In clinical studies, doses of 200 to 800 mg in divided doses are typically used.

Each (one) capsule contains:
Phosphatidyl Serine Complex  500 mg
(Delivering 100 mg Phosphatidyl Serine per cap)

Product # 178 (30 SoftGel Capsules) $27.95

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REFERENCES
1.) Hirabayashi Y, Furuya S. Roles of l-serine and sphingolipid synthesis in brain development and neuronal survival. Prog Lipid Res. 2008 Feb 15 [Epub ahead of print].
2.) Vance JE. Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically-related aminophospholipids. J Lipid Res. 2008 Jan 19 [Epub ahead of print]
3.) Cenacchi, B, Bertoldin T, Farina C, Fiori M.G., Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Clin. Exp. Res.), 1993, 5: 123-33.
4.) Crook, T.H., Tinklenburg, J, Yesavage J, Petrie W, Nunzie M.G., and Massari, D.C. Effects of phosphatidylserine in age-associated memory impairment. Neurol, 1991. 41: 644-9.
5.) Gindin, J, et al., 1995. The Effect of Plant Phosphatidylserine on Age-Associated Memory Impairment and Mood in the Functioning Elderly. Rehovot, Israel: Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital.
6.) Amaducci, L and the SMID Group. Phosphatidylserine in the treatment of Alzheimers disease: results of a multicenter study. Psychopharmacol. Bulletin, 1988, 24: 130-4.
7.) Cenacchi, B, Bertoldin T, Farina C, Fiori M.G., Crepaldi G. Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging (Clin. Exp. Res.), 1993, 5: 123-33.
8.) Crook, T.H., Tinklenburg, J, Yesavage J, Petrie W, Nunzie M.G., and Massari, D.C. Effects of phosphatidylserine in age-associated memory impairment. Neurol, 1991. 41: 644-9.
9.) Crook, T.H., Petrie W, Wells C, Massari, D.C. Effects of phosphatidylserine in Alzheimers disease. Psychopharmacol. Bulletin,, 1992. 28: 61-6.
10.) Delwaide, P.J., Gyselynk-Mambourg A.M., Hurlet A. and Ylieff M. Double-blind randomized controlled study of phosphatidylserine in demented patients. Acta Neurol. Scand, 1986. 73:136-40.
11.) Engel, R.R., Satzger W, Gunther W, Kathmann N, Bove D, Gerkes, Munch U and Hippius H. Double-blind cross-over study of phosphatidylserine vs. placebo in subjects with early cognitive deterioration of the Alzheimer type. Eur. Neuropsychopharmacol, 1992. 2: 149-55.
12.) Funfgeld, E.W., Baggen, M, Nedwidek,P, et al. Double-blind study with phosphatidylserine (PS) in Parkinsonian patients with senile dementia of Alzheimers type (SDAT). Progr. Clin. Biol. Res, 1989. 317: 1235-46.
13.) Gindin, J, et al., 1995. The Effect of Plant Phosphatidylserine on Age-Associated Memory Impairment and Mood in the Functioning Elderly. Rehovot, Israel: Geriatric Institute for Education and Research, and Department of Geriatrics, Kaplan Hospital.
14.) Hershowitz M, et al. Long-term treatment of dementia Alzheimer type with phosphatidylserine: effect on cognitive functioning and performance in daily life. In, Bazan NG, et al (eds) Phospholipids in the Nervous System: Biochemical and Molecular Pathology, 1989. Padua, Italy: Liviana Press.
15.) Maggioni, M, Picotti, G.B., Bondiolotti ,G.P., Panerai, A. Cenacchi, T. Nobil, P. and Brambilla, F. Effects of phosphatidylserine therapy in geriatric patients with depressive disorders. Acta Psychiatr. Scand. 1990. 81: 265-70.
16.) Rosadini, G, Sannita ,W.G., Nobili, F, and Cenacchi, T. Phosphatidylserine: quantitative EEG effects in healthy volunteers. Neuropsychobiol, 1991. 24: 42-8.
17.) Villardita, C, Griolis, S, Salmeri, G,et al.Multicentre clinical trial of brain phosphatidylserine in elderly patients with intellectual deterioration. Clin. Trials J., 1987. 24: 84-93.
18.) McDaniel MA, Maier SF, Einstein GO. (Nov-Dec 2003). "Brain-specific nutrients: a memory cure?". Nutrition 19 (11-12): 957-75.
19.) Micheau J, Riedel G. (Apr 1999). "Protein kinases: which one is the memory molecule?". Cell Mol Life Sci. 55 (4): 534-48.
20.) Monteleone, P, Beinat, L, Tanzillo,C, Maj, M, and Kemali, D. Effects of phosphatidylserine on the neuroendocrine response to physical stress in humans. Neuroendocrinol, 1990. 52: 243-8.
21.) Monteleone, P, Maj,M, Beinat,L, Natale,M, and Kemali,D. Blunting by chronic phosphatidylserine administration of the stress-induced activation of the hypothalamos-pituitary-adrenal axis in healthy men. Eur. J. Clin.Pharmacol, 1992. 41: 385-8.

    

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