Lithium Orotate

Protect and Renew Brain Cells

Lithium is a unique but often overlooked mineral with many health uses. It is a natural mineral in the same family as sodium and potassium.

Most people are familiar with the lithium salts (carbonate and citrate) used to treat manic-depression (bipolar disorder). This form of lithium is not easily absorbed, so extremely high doses must be used (1200mg of lithium carbonate per dose, for example). At these doses, lithium is highly toxic. The toxic salt forms are available only by prescription.

Lithium orotate is 20-times more biologically active than other forms of lithium, and is extremely safe. In orotate form, lithium acts as a mineral supplement that may be beneficial for:

• protecting and renewing brain cells (1-8, 17)
• Alzheimer's prevention and possibly even reversal (9-16)
• migraine and cluster headaches (17-20)
• depression (21-24,30)
• low white blood cell count (especially after chemotherapy) (25-27)
• spatial memory improvement ("Where did I park my car?") (28)
• alcoholism (29-31)
• Meniere’s syndrome (17)
• Improves cognitive impairment in HIV+ patients (32)

Each capsule contains: 4.8mg of elemental lithium.

Recommended dose: 1 capsule 2 times per day with meals or as recommended by a physician.

NOTE: DO NOT discontinue prescribed lithium salts for bipolar disorder without the guidance of a physician.

Lithium Orotate Product # 2309 (120 Capsules) $17.95

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Please Note: 130 mg of Lithium Orotate provides 4.8 mg of elemental lithium.
To understand this you can think of the Lithium Orotate as being the "carrier" which provides the physiologic dose of 4.8 mg of elemental lithium in a highly biologically available and active form.

Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
Lithium Orotate (providing 4.8 mg elemental lithium)	130 mg	*
*Daily Value not established
Other Ingredients: Microcrystalline cellulose and hydroxypropylmethylcellulose (vegetarian capsule) and magnesium stearate. Contains no added sugar, starch, salt, wheat, gluten, corn, coloring, dairy products, flavoring or preservatives. Keep container tightly closed in a cool, dry and dark place. Keep out of reach of children.

References

1.) Lithium-induced increase in human brain grey matter. Lancet 2000; 356: 1,241-1,242.
2. ) Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience 2003; 117(1): 55-61.
3.) Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Crit Rev Neurobiol. 2004;16(1-2):83-90.
4.) Lithium at 50: have the neuroprotective effects of this unique cation been overlooked? Biol Psychiatry. 1999 Oct 1;46(7):929-40.
5.) Neuroprotective effects of lithium in cultured cells and animal models of diseases.Bipolar Disord. 2002 Apr;4(2):129-36.
6.) Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release. J Biol Chem. 2007 Jun 22;282(25):18057-68. Epub 2007 May 4.
7.) Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. Journal of Pharmacology and Experimental Therapeutics 1998; 286(1): 539-547.
8.) Lithium exerts robust neuroprotective effects in vitro and in the CNS in vivo: Therapeutic implications. Neuropsychopharmacology 2000; 23(S2): S39.
9.) A feasibility and tolerability study of lithium in Alzheimer's disease. Int J Geriatr Psychiatry.2008 Jan 8 [Epub ahead of print].
10.) Lithium for prevention of Alzheimer's disease. Br J Psychiatry. 2007 Oct;191:361; author reply 361-2.
11.) Lithium: a novel treatment for Alzheimer's disease? Expert Opin Drug Saf. 2007 Jul;6(4):375-83.
12.) In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked? Biol Psychiatry. 2007 Jul 1;62(1):4-6.
13.) Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder. Br J Psychiatry. 2007 Apr;190:359-60.
14.) Implications of the neuroprotective effects of lithium for the treatment of bipolar and neurodegenerative disorders. Pharmacopsychiatry.
2003 Nov;36 Suppl 3:S250-4.
15.) Lithium and dementia: a preliminary study. Prog Neuropsychopharmacol Biol Psychiatry. 2006 Aug 30;30(6):1125-8.Epub 2006 Jun 6.
16.) Lithium inhibits amyloid secretion in COS7 cells transfected with amyloid precursor protein C100. Neuroscience Letters 2002; 321(1-2): 61-64
17.) A review of clinical trials of lithium in neurology. Pharmacol Biochem Behav. 1984;21 Suppl 1:57-64.
18.) Lithium treatment of chronic cluster headaches.Br J Psychiatry. 1978 Dec;133:556-8.
19.) Chronic cluster headache: response to lithium treatment. J Neurol. 1979 Sep;221(3):181-5.
20.) Lithium carbonate in cluster headache: assessment of its short- and long-term therapeutic efficacy.Cephalalgia. 1983 Jun;3(2):109-14.
21.) Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Mol Psychiatry. 2007 Oct 30 [Epub ahead of print]
22.) The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Mol Psychiatry. 2007 Oct 9 [Epub ahead of print]
23.) Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness.J Clin Psychiatry. 2000;61 Suppl 9:82-96.
24.) Lithium for maintenance treatment of mood disorders. Cochrane Database Syst Rev. 2001;(2):CD003013.
25.)Effects of lithium carbonate on hematopoietic cells in patients with persistent neutropenia following chemotherapy or radiotherapy.J Trace Elem Med Biol. 2002;16(2):91-7.
26.) Effects of lithium on thrombopoiesis in patients with low platelet cell counts following chemotherapy or radiotherapy. Biol Trace Elem Res. 2001 Nov;83(2):139-48.
27.) A review of clinical trials of lithium in medicine. Pharmacol Biochem Behav.1984;21 Suppl 1:51-5.
28.) Lithium and spatial memory: A new pathway? Society for Neuroscience Abstracts 2001; 27(1): 845.
29.)Lithium orotate in the treatment of alcoholism and related conditions. Alcohol. 1986 Mar-Apr;3(2):97-100.
30.) Lithium. Conn Med. 1990 Mar;54(3):115-26.
31.) Evaluation of lithium therapy for alcoholism. J Clin Psychiatry. 1984 Dec;45(12):494-9.
32.) Lithium improves HIV-associated neurocognitive impairment." AIDS. 2006 Sep 11;20(14):1885-8.