Cox-2 Support
Botanical support for normal inflammatory response
Cyclo-oxygenase 1 and 2 (COX-1 and COX-2) are enzymes which convert essential fatty acids (especially Omega-6) to prostaglandins. Although the body requires prostaglandins, these intracellular messengers are found at excessively high levels at sites of inflammation.
Anti-inflammatory drugs such as celecoxib (Celebrex), rofecoxib (Vioxx) and valdecoxib (Bextra) work by blocking the COX-2 enzyme but not the COX-1 enzyme. Originally felt to be safer than older NSAIDS such as aspirin, ibuprofen and naproxen, the COX-2 inhibiting drugs are now known to cause increased risk of kidney failure, heart attack, stroke, sudden cardiac death, high blood pressure, fluid retention and severe stomach pain.
Fortunately, safe alternatives exist for normalizing inflammatory processes.
Turmeric, the bright yellow spice herb, has been shown to be a natural COX-2 inhibitor, and drug companies are rushing to develop synthetic alternatives.
Bromelain, the digestive enzyme from pineapple, is one of the most well-studied anti-inflammatory herbs of all time.
Ginger inhibits COX-1 enzymes and prevents blood clotting more effectively than aspirin.
Boswellia, also known "Indian frankincense," has been used traditionally for centuries as an anti-inflammatory agent.
White willow bark is the source of natural salicin (aspirin).
Phellodendron is a natural COX-2 inhibitor, found to be helpful in the management and potential treatment of inflammatory diseases. Phellodendron has been used for centuries in Chinese Medicine.
COX-2 Support combines these potent natural anti-inflammatory herbs in therapeutic doses to offer a safe, natural and effective alternative to dangerous COX-2 drugs.
Suggested dose: 3 capsules, 1-2 times daily between meals.
COX-2 Support - Product # 185 (90 Capsules) $29.97
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Each serving of 3 capsules contains:
| Phellodendron amurense bark extract |
250 mg |
Turmeric (Curcuma longa) rhizome extract
(standardized to contain 95% [190 mg] curcuminoids) |
200 mg |
Ginger (Zingiber officinale) rhizome extract
(standardized to contain 5% [11.25 mg] gingerols) |
225 mg |
White Willow (Salix alba) bark extract
(standardized to contain 15% [30 mg] salicin) |
200 mg |
Boswellia serrata gum resin extract
(standardized to contain 40% [80 mg] boswellic acids) |
200 mg |
Devil's claw root extract (Harpagophytum procumbens)
(standardized to contain 5% [11.25 mg] iridoid glycosides) |
225 mg |
| Green tea leaf extract (decaffeinated) (Camellia sinensis) |
100 mg |
Bromelain (from pineapple [Ananas comosus] stem)
(standardized to 2400 GDUs/g or, 360GDUs) |
150 mg |
| Papain |
100 mg |
| Protease |
25 mg |
| Grape (Vitis vinifea) seed extract |
10 mg |
| Rosemary (Rosemarinus officinalis) leaf extract |
50 mg |
| Quercitin |
50 mg |
Polygonum cuspidatum root extract 200:1
(standardized to contain 50% [8 mg] phytoestrogens) |
16 mg |
| Other ingredients: Gelatin, glycerin, water (capsules), (May contain one or more of the following; magnesium stearate, cellulose, vegetable stearin and silica). |
References:
Enid Morales, Pharm.D., Jeffrey J. Mucksavage, Pharm.D. Cyclooxygenase-2 Inhibitor-Associated Acute Renal Failure: Case Report With Rofecoxib and Review of the Literature. Pharmacotherapy. 2002; 22(10):1317-1321.
Nurtjahja-Tjendraputra E, Ammit AJ, Roufogalis BD, Tran VH, Duke CC.
Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thromb Res. 2003;111(4-5):259-65.
