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CoQ10 (ubiquinone)
Super-Energizer and Potent Antioxidant
CoQ10 is a naturally-occurring
antioxidant produced in the human body. It is vitally involved in
energy production. CoQ10 functions as an "energizer" to
mitochondria, the body's energy producing units. Mitochondria, which
produce energy the body's "energy currency," ATP, require CoQ10 to
"spark" their production of energy units (ATP). Muscles, and the
heart in particular, have high requirements for CoQ10.
CoQ10 is a potent antioxidant beneficial
for:
-
Heart Disease (angina, arrhythmia, atherosclerosis,
cardiomyopathy, heart failure, congestive heart failure,
myocardial infarction (1-18)
- High Blood Pressure
(1,3,4,14, 53, 55)
- Neurological disease
(Alzheimer's, Huntington's, Parkinson's) (19-37)
- Immune deficiency and AIDS
(40-45,52)
- Periodontal disease
(38-39)
- Cancer (40, 44-49)
- Chemotherapy side-effects
(50-52)
- Diabetes (53-56)
- Muscular dystrophy
(57-58)
- fatigue / chronic fatigue /
fibromyalgia (59-61)
- migraine headache
(62-63)
- enhancing athletic
performance (64-68)
-
male infertility (69-73)
CoQ10 is produced by the body, but
age, nutrient deficiencies, disease and some medications can lower
the body's CoQ10 levels.
Cholesterol-lowering drugs (statins) deplete CoQ10.
(15,54,74-77)
Studies have shown that the
oil-preserved form is up to 3 times better absorbed than other
forms. (78-80)
Although many claims are currently made for a "new" form (ubiquinol)
being "more absorbable" than ubiquinone, this has never been proven
or well-studied. Learn more about this issue here:
Ubiquinone (CoQ10) versus Ubiquinol: Which Is Better?
Suggested dose:
50-100 mg per day for health maintenance
and anti-aging / longevity programs.
200 to 400 mg per day for heart problems, cancer, weight loss
programs and other indications.
Studies performed by the National Institutes of Health (NIH)
using Vitaline ™ brand CoQ10, have used
300-400 mg per day.
Each Capsule contains:
50 or 100 mg capsules are Wellness Club brand oil-preserved
CoQ10 in easy to swallow gel Caps with Vitamin E & Beta carotene as
natural preservatives.
300 and 400mg tablets are Vitaline/Integrative Therapeutics chewable
wafers, the exact formulas used in the NIH Parkinson's trials.
Product # 134 (60 softgel Caps 50 mg)
35.95
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Product # 135 (60 softgel Caps 100 mg)
62.95
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Product # N313 (60 chewable wafers 300 mg)
97.00
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Product # N314 (90 chewable wafers 400 mg)
197.00
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References:
1.) Adarsh K, Kaur H, Mohan V. Coenzyme Q10 (CoQ10) in isolated diastolic heart
failure in hypertrophic cardiomyopathy (HCM). Biofactors. 2008;32(1-4):145-9.
2.) Berman M, Erman A, Ben-Gal T, Dvir D, Georghiou GP, Stamler A, Vered Y,
Vidne BA, Aravot D. Coenzyme Q10 in patients with end-stage heart failure
awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin
Cardiol. 2004 May;27(5):295-9.
3.) Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves
blood pressure and glycaemic control: a controlled trial in subjects with type 2
diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
4.) Kumar A, Kaur H, Devi P, Mohan V. Role of Coenzyme Q10 (CoQ10) in Cardiac
disease, Hypertension and Meniere- like syndrome. Pharmacol Ther. 2009 Jul 25. [Epub
ahead of print]
5.) Langsjoen PH, Folkers K, Lyson K, Muratsu K, Lyson T, Langsjoen P.
Pronounced increase of survival of patients with cardiomyopathy when treated
with coenzyme Q10 and conventional therapy. Int J Tissue React.
1990;12(3):163-8.
6.) Langsjoen PH, Folkers K, Lyson K, Muratsu K, Lyson T, Langsjoen P. Effective
and safe therapy with coenzyme Q10 for cardiomyopathy. Klin Wochenschr. 1988 Jul
1;66(13):583-90.
7.) Langsjoen P, Langsjoen A, Willis R, and Folkers K. The Aging Heart: Reversal
of Diastolic Dysfunction Through the Use of Oral CoQ10 in the Elderly.
Anti-Aging Medical Therapeutics. Klatz RM and Goldman R (eds.). Health Quest
Publications. 1997;113-120.
8.) Langsjoen PH, Langsjoen A, Willis R, Folkers K. Treatment of hypertrophic
cardiomyopathy with coenzyme Q10. Mol Aspects Med. 1997;18(S):s145-s151.
9.) Langsjoen PH, Vadhanavikit S, Folkers K. Response of patients in classes III
and IV of cardiomyopathy to therapy in a blind and crossover trial with coenzyme
Q10. Proc Natl Acad Sci U S A. 1985 Jun;82(12):4240-4.
10.) Mabuchi H, Higashikata T, Kawashiri M, Katsuda S, Mizuno M, Nohara A, Inazu
A, Koizumi J, Kobayashi J. Reduction of serum ubiquinol-10 and ubiquinone-10
levels by atorvastatin in hypercholesterolemic patients. Journal of Atheroscler
Thromb. 2005;12(2):111-9.
11.) Molyneux SL, Florkowski CM, George PM, Pilbrow AP, Frampton
CM, Lever M, Richards AM. Coenzyme Q10: an independent predictor of mortality in
chronic heart failure. J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41.
12.) Mortensen SA. Overview on coenzyme Q10 as adjunctive therapy in chronic
heart failure. Rationale, design and end-points of "Q-symbio"--a multinational
trial. Biofactors. 2003;18(1-4):79-89.
13.) Mortensen S.A., Vadhanavikit S., Muratsu K., Folkers K. (1990) Coenzyme
Q10: Clinical benefits with biochemical correlates suggesting a scientific
breakthrough in the management of chronic heart failure. In: Int. J. Tissue
React., Vol. 12 (3), pp 155-162.
14.) Rosenfeldt F, Hilton D, Pepe S, Krum H. Systematic review of effect of
coenzyme Q10 in physical exercise, hypertension, and heart failure. Biofactors.
2003;18(1-4):91-100.
15.) Silver MA, Langsjoen PH, Szabo S, Patil H, Zelinger A. Effect of
atorvastatin on left ventricular diastolic function and ability of coenzyme Q10
to reverse that dysfunction. Am J Cardiol. 2004 Nov 15;94(10):1306-10.
16.) Singh RB; Wander GS et al Randomized, double-blind placebo-controlled trial
of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc Drugs
Ther, 12(4):347-53 1998 Sep.
17.) Singh RB; Wander GS et al Cardiovasc Drugs Ther, 12(4):347-53 1998 Sep.
18.) Weant KA, Smith KM. The role of coenzyme Q10 in heart failure. Ann
Pharmacother. 2005;39(9):1522-6.
19.) Beal MF. Coenzyme Q10 as a possible treatment for neurodegenerative
diseases. Free Radic Res. 2002 Apr;36(4):455-60.
20.) Fallon J, Matthews RT, Hyman BT, Beal MF. MPP+ produces progressive
neuronal degeneration which is mediated by oxidative stress. Exp Neurol. 1997
Mar;144(1):193-8.
21.) Feigin A, Kieburtz K, Como P, Hickey C, Claude K, Abwender D, Zimmerman C,
Steinberg K, Shoulson I. Assessment of coenzyme Q10 tolerability in Huntington's
disease. Mov Disord. 1996;11(3):321-323.
22.) Ferrante KL, Shefner J, Zhang H, et al. Tolerance of high-dose (3,000
mg/day) coenzyme Q10 in ALS. Neurology. 2005 Dec 13;65(11):1834-1836.
23.) Flint Beal M, Matthews RT, Tieleman A, Shults CW. Coenzyme Q10 attenuates
the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal
dopamine and dopaminergic axons in aged mice. Brain Res. 1998;783:109-114.
24.) Flint Beal M, Matthews RT. Coenzyme Q10 in the central nervous system and
its potential usefulness in the treatment of neurodegenerative diseases. Mol
Aspects Med. 1997;18(S);s169-s179.
25.) Flint Beal M, Henshaw DR, Jenkins BG, Rosen BR, Schulz JB. Coenzyme Q10 and
nicotinamide block striatal lesions produced by the mitochondrial toxin malonate.
Ann Neurol. 1994;36:882-888.
26.) Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal
MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions
in models of neurodegenerative illness using spectroscopic imaging. J Cereb
Blood Flow Metab. 1996 May;16(3):450-61.
27.) Koroshetz WJ, Jenkins BG, Rosen BR, Flint Beal M. Energy metabolism defects
in Huntington's disease and effects of coenzyme Q10. Ann Neurol.
1997;41:160-165.
28.) Matthews RT, Yang L, Brown S, Baik MF. Coenzyme Q10 administration
increases brain mitochondrial concentration and exerts neuroprotective effects.
Proc Natl Acad Sci USA. 1998;95:8892-8897.
29.) Schilling G, Coonfield ML, Ross CA, Borchelt DR. Coenzyme Q10 and
remacemide hydrochloride ameliorate motor deficits in a Huntington's disease
transgenic mouse model. Neurosci Lett. 2001 Nov 27;315(3):149-53.
30.) Shults CW, Oakes D, Kieburtz K, et al. Effects of Coenzyme Q10 in Early
Parkinson's Disease. Arch Neurol. 2002:59:1541-1550.
31.) Schulz B, Matthews RT, Henshaw DR, Beal MF. Neuroprotective strategies for
treatment of lesions produced by mitochondrial toxins: implications for
neurodegenerative diseases. Neuroscience. 1996;71(4):1043-1048.
32.) Shults CW, Flint Beal M, Fontaine D, Nakano K, Haas RH. Absorption,
tolerability, and effects on mitochondrial activity of oral coenzyme Q10 in
parkinsonian patients. Neurology. 1998;50:793-795.
33.) Shults CW, Haas RH, Passov D, Beal MF. Coenzyme Q10 levels correlate with
the activities of complexes I and II/III in mitochondria from parkinsonian and
nonparkinsonian subjects. Ann Neurol. 1997 Aug;42(2):261-4.
34.) Schulz JB, Henshaw R, Matthews RT, Flint Beal M. Coenzyme Q10 and
nicotinamide and a free radical spin trap protect against MPTP neurotoxicity.
Exp Neurol. 1995;132:279-283.
35.) Shults CW, Flint Beal M, Song D, Fontaine D. Pilot trial of high dosages of
coenzyme Q10 in patients with Parkinson's disease. Exp Neurol. 2004
Aug;188(2):491-4.
36.) The Huntington Study Group. A Randomized, Placebo-Controlled Trial of
Coenzyme Q10 and Remacemide in Huntington's Disease. Neurology. 2001:57:397-404.
37.) Yang L, Calingasan NY, Wille EJ, Cormier K, Smith K, Ferrante RJ, Beal MF.
Combination therapy with coenzyme Q10 and creatine produces additive
neuroprotective effects in models of Parkinson’s and Huntington’s diseases. J
Neurochem. 2009 Jun;109(5):1427-39.
38.) Hanioka T, Tanaka M, Ojima M, Shizukuishi S, Folkers K. Effect of topical
application of coenzyme Q10 on adult periodontitis. Mol Aspects Med. 1994;15
Suppl:s241-8.
39.)Nakamura R, Littarru GP, Folkers K, Wilkinson EG. Study of CoQ10-enzymes in
gingiva from patients with periodontal disease and evidence for a deficiency of
coenzyme Q10. Proc Natl Acad Sci U S A. 1974 Apr;71(4):1456-60.
40.) Folkers K, Hanioka T, Xia LJ, McRee JT Jr, Langsjoen P. Coenzyme Q10
increases T4/T8 ratios of lymphocytes in ordinary subjects and relevance to
patients having the AIDS related complex. Biochem Biophys Res Commun. 1991 Apr
30;176(2):786-91.
41.) Folkers K, Langsjoen P, Nara Y, Muratsu K, Komorowski J, Richardson PC,
Smith TH. Biochemical deficiencies of coenzyme Q10 in HIV-infection and
exploratory treatment. Biochem Biophys Res Commun. 1988 Jun 16;153(2):888-96.
42.) Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in
immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.
43.) Ravaglia G, Forti P, Maioli F, Bastagli L, Facchini A, Mariani E, Savarino
L, Sassi S, Cucinotta D, Lenaz G. Effect of micronutrient status on natural
killer cell immune function in healthy free-living subjects aged >/=90 y. Am J
Clin Nutr. 2000 Feb;71(2):590-8.
44.) Folkers K, Morita M, McRee J Jr. The activities of coenzyme Q10 and vitamin
B6 for immune responses. Biochem Biophys Res Commun. 1993 May 28;193(1):88-92.
45.) Folkers K, Brown R, Judy WV, Morita M. Biochem Biophys Res Commun. 1993 Apr
15;192(1):241-5.Survival of cancer patients on therapy with coenzyme Q10.
46.) Judy WV. Nutritional intervention in cancer prevention and treatment.
American College for Advancement in Medicine Spring Conference, Ft. Lauderdale,
FL. May 3, 1998.
47.) Lockwood K, Moesgaard S, Folkers K. Partial and complete regression of
breast cancer in patients in relation to dosage of coenzyme Q10. Biochem Biophys
Res Commun 1994;199:1504–8.
47.) Lockwood K, Moesgaard S, Hanioka T, Folkers K. Apparent partial remission
of breast cancer in 'high risk' patients supplemented with nutritional
antioxidants, essential fatty acids and coenzyme Q10. Mol Aspects Med. 1994;15
Suppl:s231-40.
48.) Lockwood K, Moesgaard S, Yamamoto T, Folkers K. Progress on therapy of
breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys
Res Commun 1995;212:172–7.
49.) Perumal SS, Shanthi P, Sachdanandam P. Energy-modulating vitamins--a new
combinatorial therapy prevents cancer cachexia in rat mammary carcinoma.Br J
Nutr. 2005 Jun;93(6):901-9.
50.) Conklin KA. Coenzyme q10 for prevention of anthracycline-induced
cardiotoxicity. Integr Cancer Ther. 2005 Jun;4(2):110-30.
51.) Domae N, Sawada H, Matsuyama E, Konishi T, Uchino H. Cardiomyopathy and
other chronic toxic effects induced in rabbits by doxorubicin and possible
prevention by coenzyme Q10. Cancer Treat Rep. 1981 Jan-Feb;65(1-2):79-91.
52.) Folkers K, Wolaniuk A. Research on coenzyme Q10 in clinical medicine and in
immunomodulation. Drugs Exp Clin Res. 1985;11(8):539-45.
53.) Chew GT, Watts GF, Davis TM, Stuckey BG, Beilin LJ, Thompson PL, Burke V,
Currie PJ. Hemodynamic effects of fenofibrate and coenzyme Q10 in type 2
diabetic subjects with left ventricular diastolic dysfunction. Diabetes Care.
2008 Aug;31(8):1502-9. Epub 2008 May 16.
54.) Hamilton SJ, Chew GT, Watts GF. Coenzyme Q10 improves endothelial
dysfunction in statin-treated type 2 diabetic patients. Diabetes Care. 2009
May;32(5):810-2. Epub 2009 Feb 19.
55.) Hodgson JM, Watts GF, Playford DA, Burke V, Croft KD. Coenzyme Q10 improves
blood pressure and glycaemic control: a controlled trial in subjects with type 2
diabetes. Eur J Clin Nutr. 2002 Nov;56(11):1137-42.
56.) Watts GF, Playford DA, Croft KD, Ward NC, Mori TA, Burke V. Coenzyme Q(10)
improves endothelial dysfunction of the brachial artery in Type II diabetes
mellitus. Diabetologia. 2002 Mar;45(3):420-6.
57.) Folkers K, Simonsen R.Two successful double-blind trials with coenzyme Q10
(vitamin Q10) on muscular dystrophies and neurogenic atrophies. Biochim Biophys
Acta. 1995 May 24;1271(1):281-6.
58.) Folkers K, Wolaniuk J, Simonsen R, Morishita M, Vadhanavikit S.Biochemical
rationale and the cardiac response of patients with muscle disease to therapy
with coenzyme Q10. Proc Natl Acad Sci U S A. 1985 Jul;82(13):4513-6.
59.) Bentler SE, Hartz AJ, Kuhn EM. Prospective observational study of
treatments for unexplained chronic fatigue. J Clin Psychiatry. 2005
May;66(5):625-32.
60.) Cordero MD, Moreno-Fernández AM, deMiguel M, Bonal P, Campa F,
Jiménez-Jiménez LM, Ruiz-Losada A, Sánchez-Domínguez B, Sánchez Alcázar JA,
Salviati L, Navas P. Coenzyme Q10 distribution in blood is altered in patients
with fibromyalgia. Clin Biochem. 2009 May;42(7-8):732-5. Epub 2008 Dec 25.
61.) Lister RE. An open, pilot study to evaluate the potential benefits of
coenzyme Q10 combined with Ginkgo biloba extract in fibromyalgia syndrome. J Int
Med Res. 2002 Mar-Apr;30(2):195-9.
62.) Sándor PS, Di Clemente L, Coppola G, Saenger U, Fumal A, Magis D, Seidel L,
Agosti RM, Schoenen J. Efficacy of coenzyme Q10 in migraine prophylaxis: a
randomized controlled trial. Neurology. 2005 Feb 22;64(4):713-5.
63.) Rozen TD, Oshinsky ML, Gebeline CA, Bradley KC, Young WB, Shechter AL,
Silberstein SD. Open label trial of coenzyme Q10 as a migraine preventive.
Cephalalgia. 2002 Mar;22(2):137-41.
64.) Cohen B, Gold D. Mitochondrial cytopathy in adults: What we know so far.
Cleveland Clinic J Medicine 2001, 68:7,625-642.
65.) Cooke M, Iosia M, Buford T, Shelmadine B, Hudson G, Kerksick C, Rasmussen
C, Greenwood M, Leutholtz B, Willoughby D, Kreider R.Effects of acute and 14-day
coenzyme Q10 supplementation on exercise performance in both trained and
untrained individuals. J Int Soc Sports Nutr. 2008 Mar 4;5:8.
66.) Gökbel H, Gül I, Belviranl M, Okudan N. The Effects Of Coenzyme Q10
Supplementation on Performance During Repeated Bouts of Supramaximal Exercise in
Sedentary Men. J Strength Cond Res. 2009 Jul 28. [Epub ahead of print]
67.) Kon M, Tanabe K, Akimoto T, Kimura F, Tanimura Y, Shimizu K, Okamoto T,
Kono I. Reducing exercise-induced muscular injury in kendo athletes with
supplementation of coenzyme Q10. Br J Nutr. 2008 Feb 20;1-7. 68.) Mizuno K,
Tanaka M, Nozaki S, Mizuma H, Ataka S, Tahara T, Sugino T, Shirai T, Kajimoto Y,
Kuratsune H, Kajimoto O, Watanabe Y. Antifatigue effects of coenzyme Q10 during
physical fatigue. Nutrition. 2008 Feb 11.
69.) Balercia G, Buldreghini E, Vignini A, Tiano L, Paggi F, Amoroso S,
Ricciardo-Lamonica G, Boscaro M, Lenzi A, Littarru G. Coenzyme Q10 treatment in
infertile men with idiopathic asthenozoospermia: a placebo-controlled,
double-blind randomized trial. Fertil Steril. 2009 May;91(5):1785-92. 70.)
Balercia G, Mancini A, Paggi F, Tiano L, Pontecorvi A, Boscaro M, Lenzi A,
Littarru GP. COENZYME Q10 AND MALE INFERTILITY. J Endocrinol Invest. 2009 May
21. [Epub ahead of print]
71.) Balercia G, Mosca F, Mantero F, Boscaro M, Mancini A, Ricciardo-Lamonica G,
Littarru G. Coenzyme Q(10) supplementation in infertile men with idiopathic
asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004
Jan;81(1):93-8.
72.) Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme
Q10: recent developments. Mol Biotechnol. 2007 Sep;37(1):31-7.
73.) Mancini A, De Marinis L, Littarru GP, Balercia G. An update of Coenzyme Q10
implications in male infertility: biochemical and therapeutic aspects.
Biofactors. 2005;25(1-4):165-74.
74.) Joy TR, Hegele RA. Narrative review: statin-related myopathy. Ann Intern
Med. 2009 Jun 16;150(12):858-68.
75.) Langsjoen PH, Langsjoen AM. The clinical use of HMG CoA-reductase
inhibitors and the associated depletion of coenzyme Q10. A review of animal and
human publications. Biofactors. 2003;18(1-4):101-11.
76.) Langsjoen PH, Langsjoen JO, Langsjoen AM, Lucas LA. Treatment of statin
adverse effects with supplemental Coenzyme Q10 and statin drug discontinuation.
Biofactors. 2005;25(1-4):147-52.
77.) Caso G, Kelly P, McNurlan MA, Lawson WE. Effect of coenzyme q10 on
myopathic symptoms in patients treated with statins. Am J Cardiol. 2007 May
15;99(10):1409-12. Epub 2007 Apr 3.
78.) Bhagavan HN, Chopra RK. Plasma coenzyme Q10 response to oral ingestion of
coenzyme Q10 formulations. Mitochondrion. 2007 Jun;7 Suppl:S78-88. Epub 2007 Mar
27.
79.) Chopra RK, Goldman R, Sinatra ST, Bhagavan HN. Relative bioavailability of
coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res
1998;68:109–13.
80.)Weiss M, Mortensen SA, Rassig MR, et al. Bioavailability of four oral
coenzyme Q10 formulations in healthy volunteers. Molec Aspects Med
1994;15:273–80. |
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