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Bromelain
Nature's Premier Anti-Inflammatory Herb
Bromelain is a mixture of sulfur-containing,
protein-digesting enzymes from the stem of Anansus cosmosis
(pineapple). Since it was introduced as a medicinal agent in
1957, more than 200 scientific papers on bromelain's medicinal uses
have appeared in the medical literature. It is one of the most
well-studied anti-inflammatory herbs known. Unless an individual
is allergic to pineapple (in which case, don't use bromelain!) the
safety profile of this herb is excellent.(2) Of all the
anti-inflammatory substances available (including drugs), bromelain
is the one I turn to first.
Bromelain has no direct immune or
antimicrobial effects. Instead, it acts to increase the effect of
other immune cells by dissolving the mucous coat that bacteria use
to "shield" themselves from the immune system. Some studies have
shown it to be as effective as antibiotics for treatment of
pneumonia, bronchitis, sinusitis and dental, skin and kidney infection.
Bromelain's actions include:
- Antiinflammatory
(1,2,7,8,10,11)
- Antiedematous (reduces swelling)
(1,2,11)
- Antitumoral (13,20)
- Antimetastatic (1,2,7,13)
- Antithrombotic (1,2,4,5,11)
- Fibrinolytic (1,2,3,4,7,11)
- Immunomodulator (2)
- Enhanced drug absorption
(especially antibiotics) (2)
- Decreased platelet aggregation
(2,5,6,7)
- Increase activity of the body's defense
system (2)
Based on it's
actions, bromelain may be useful in:
- Thrombosis
(1,2,4,5)
- Cardiovascular disease
(1-7,11)
- Cancer
(1,2,7,11,13,17,18,19,20)
- All types of infection
(sinusitis, pneumonia, bronchitis, sepsis) (2,8,23)
- Osteo Arthritis
(8,15,16)
- Rheumatoid Arthritis
(19,21,22)
- Inflammatory
bowel disease (8,10,12,15)
Suggested Dose: Begin with 2 capsules,
3 to 4 times per day between meals for acute infection or severe
inflammation. Decrease dose to 1 capsule, 3 to 4 times daily
as symptoms improve.
Each (1) capsule contains:
400 mg of
2,400 mcu-strength bromelain.
This is one of the highest potencies
of bromelain available. Don't be fooled! It's not just the "milligrams per
capsule," but the POTENCY of the enzyme (the "mcu"or
GDU) that determines
OVERALL potency. Our Wellness Club brand of
bromelain offers the highest potency and purity available!
Bromelain
Product # 182 (60 Caps)
$17.00
Enter Quantity Desired and Click "Add To Cart" Button
We also now have the larger-sized bottle,
offering further savings and convenience for those who take bromelain
regularly.
Bromelain
Product # 183 (120 Caps)
$32.00 Enter Quantity Desired and Click "Add To Cart" Button
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References
1.) Tysnes BB, Maurer HR, Porwol T, Probst B, Bjerkvig R, Hoover F. Bromelain
reversibly inhibits invasive properties of glioma cells. Neoplasia. 2001
Nov-Dec;3(6):469-79.
2.) Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol
Life Sci. 2001 Aug;58(9):1234-45.
3.) Ako H, Cheung AH, Matsuura PK. Isolation of a fibrinolysis enzyme activator
from commercial bromelain. Arch Int Pharmacodyn Ther. 1981 Nov;254(1):157-67.
4.) Felton GE. Fibrinolytic and antithrombotic action of bromelain may eliminate
thrombosis in heart patients. Med Hypotheses. 1980 Nov;6(11):1123-33.
5.) Metzig C, Grabowska E, Eckert K, Rehse K, Maurer HR. Bromelain proteases
reduce human platelet aggregation in vitro, adhesion to bovine endothelial cells
and thrombus formation in rat vessels in vivo. In Vivo. 1999 Jan-Feb;13(1):7-12.
6.) Gläser D, Hilberg T. The influence of bromelain on platelet count and
platelet activity in vitro. Platelets. 2006 Feb;17(1):37-41.
7.) Taussig SJ, Batkin S.Bromelain, the enzyme complex of pineapple (Ananas
comosus) and its clinical application. An update. J Ethnopharmacol. 1988
Feb-Mar;22(2):191-203.
8.) Hale LP, Greer PK, Trinh CT, James CL. Proteinase activity and stability of
natural bromelain preparations. Int Immunopharmacol. 2005 Apr;5(4):783-93.
9.) Braun JM, Schneider B, Beuth HJ.Therapeutic use, efficiency and safety of
the proteolytic pineapple enzyme Bromelain-POS in children with acute sinusitis
in Germany.In Vivo. 2005 Mar-Apr;19(2):417-21.
10.) Hale LP.Proteolytic activity and immunogenicity of oral bromelain within
the gastrointestinal tract of mice. Int Immunopharmacol. 2004 Feb;4(2):255-64.
11.) Lotz-Winter H. On the pharmacology of bromelain: an update with special
regard to animal studies on dose-dependent effects. Planta Med. 1990
Jun;56(3):249-53.
12.) Hale LP, Greer PK, Trinh CT, Gottfried MR. Treatment with oral bromelain
decreases colonic inflammation in the IL-10-deficient murine model of
inflammatory bowel disease. Clin Immunol. 2005 Aug;116(2):135-42.
13.) Báez R, Lopes MT, Salas CE, Hernández M. In vivo antitumoral activity of
stem pineapple (Ananas comosus) bromelain.Planta Med. 2007 Oct;73(13):1377-83.
Epub 2007 Sep 24.
14.) Onken JE, Greer PK, Calingaert B, Hale LP.Bromelain treatment decreases
secretion of pro-inflammatory cytokines and chemokines by colon biopsies in
vitro. Clin Immunol. 2008 Mar;126(3):345-52. Epub 2007 Dec 21.
15.) Akhtar NM, Naseer R, Farooqi AZ, Aziz W, Nazir M. Oral enzyme combination
versus diclofenac in the treatment of osteoarthritis of the knee--a double-blind
prospective randomized study. Clin Rheumatol. 2004 Oct;23(5):410-5. Epub 2004
Jul 24.
16.) Walker AF, Bundy R, Hicks SM, Middleton RW.Phytomedicine. 2002
Dec;9(8):681-6.Bromelain reduces mild acute knee pain and improves well-being in
a dose-dependent fashion in an open study of otherwise healthy adults.
17.) Beuth J. Proteolytic enzyme therapy in evidence-based complementary
oncology: fact or fiction? Integr Cancer Ther. 2008 Dec;7(4):311-6.
18.) Stopper H, Schinzel R, Sebekova K, Heidland A. Genotoxicity of advanced
glycation end products in mammalian cells. Cancer Lett. 2003 Feb
20;190(2):151-6.
19.) Desser L, Holomanova D, Zavadova E, Pavelka K, Mohr T, Herbacek I. Oral
therapy with proteolytic enzymes decreases excessive TGF-beta levels in human
blood. Cancer Chemother Pharmacol. 2001 Jul;47 Suppl:S10-5.
20.) Eckert K, Grabowska E, Stange R, Schneider U, Eschmann K, Maurer HR.
Effects of oral bromelain administration on the impaired immunocytotoxicity of
mononuclear cells from mammary tumor patients. Oncol Rep. 1999
Nov-Dec;6(6):1191-9.
21.) Rovenská E, Svík K, Stancíková M, Rovenský J. Inhibitory effect of enzyme
therapy and combination therapy with cyclosporin A on collagen-induced
arthritis. Clin Exp Rheumatol. 2001 May-Jun;19(3):303-9.
22.) Leipner J, Iten F, Saller R. Therapy with proteolytic enzymes in rheumatic
disorders. BioDrugs. 2001;15(12):779-89.
23.) Shahid SK, Turakhia NH, Kundra M, Shanbag P, Daftary GV, Schiess W.
Efficacy and safety of phlogenzym--a protease formulation, in sepsis in
children. J Assoc Physicians India. 2002 Apr;50:527-31.
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