Maxi Marine O-3
High Potency Enteric Coated Ultra-Pure Essential Fatty Acids From Norwegian
Arctic-Harvested Fish
Maxi Marine O-3 is an ultra-pure, ultra-high potency
fish oil from anchovies and sardines harvested in pristine Norwegian Arctic
waters. Purity is further assured by molecular distillation and every batch is
verified by an independent third-party lab to be free of PCB's, heavy metals and
pesticides. Vitamin E (mixed tocopherols) is added to maintain maximum freshness
and enteric coating ensures no "fishy" after-taste.
EPA and DHA, the "active ingredients" in fish oil, are long-chain Omega-3
Essential Fatty Acids that differ from short-chain Omega-3's found in plant
sources. EPA and DHA are beneficial for Cardiovascular (Heart) Health,
Alzheimer’s Disease and other Dementias, Mental Health, Child Development,
Attention-Deficit Disorders and Social/Cognitive Development, Diabetes,
Inflammatory Diseases (rheumatoid arthritis, IBS/Crohn’s, asthma, infertility,
etc.) and Cancer.
EPA/DHA (which occur together in fish oils) have numerous studies supporting
their antiinflammatory properties and use in multiple hyper-inflammatory and
autoimmune states. (14-24) EPA and DHA decrease NK cell activity (14,24-29), and
this effect is synergistic when both EPA and DHA are used together.(18,28). EPA,
but not ALA, also decreases TNF-alpha.(23-25).
While ALA (flax oil) has some similar benefits, it must be taken in
significantly higher doses because ultimately the anti-inflammatory effect is
seen when ALA is converted to EPA, as follows:
ALA (flax oil) >>> SDA (stearidonic acid) >>> EPA (fish oil) >>>
Prostaglandin E3
An estimated 0.07% of ALA is converted to EPA in healthy people (30,31), but
the conversion rate may be less when the delta-6-desaturase (d6d) enzyme is
underfunctioning or when there is high competition from dietary Omega-6's (both
use the d6d enzyme). Assuming that converting enzymes are normal in a fertility
clinic patient, a dose comparison would be 14 grams of flax oil vs. 1 grams of
fish oil.
Studies have shown that ALA increases EPA but not DHA.(31) Some studies have
shown that ALA does not reduce inflammatory markers (23,29). For these reasons,
fish oil is preferrable to flax oil for raising EPA/DHA levels (33).
Suggested Use: Adults take one or two capsules daily with meals or
more if directed by your health care provider. Please note that the EPA/DHA
content of Maxi Marine O-3 (780mg total) is two and a half times more
concentrated than most fish oils.
Because Maxi Marine is so concentrated it is a much more economical choice
for those using higher doses of these important oils. Our regular brand of
Ultra-Pure Fish Oil costs approximately 67 cents per gram while our
higher-potency Maxi Marine O-3 is only 58 cents per gram. Higher potency means
fewer capsules per day, representing significant cost savings.
STORAGE: Store in a cool place and keep out of reach of children.
Contains No wheat, gluten, corn protein, yeast, dairy, artificial colors,
sweeteners or preservatives.
Product # N311 - Maxi Marine O3 - 120 softgels - $54.95
Enter Quantity Desired and Click "Add To Cart" Button
References: 14.) Mukaro VR, Costabile M,
Murphy KJ, Hii CS, Howe PR, Ferrante A. Leukocyte numbers and function in
subjects eating n-3 enriched foods: selective depression of natural killer cell
levels. Arthritis Res Ther. 2008;10(3):R57. Epub 2008 May 14.
CONCLUSION: The data show that regular long-term consumption of n-3 enriched
foods leads to lower numbers of NK cells and neutrophil iodination activity but
higher lymphotoxin production by lymphocytes. These changes are consistent with
decreased inflammatory reaction and
tissue damage seen in patients with inflammatory disorders receiving n-3 LCPUFA
supplementation.
15.) Calder PC. Dietary modification of inflammation with lipids. Proc Nutr Soc.
2002 Aug;61(3):345-58. CONCLUSION: EPA is anti-inflammatory
16.) Calder PC. N-3 polyunsaturated fatty acids and inflammation: from molecular
biology to the clinic. Lipids. 2003 Apr;38(4):343-52.
CONCLUSION: EPA is anti-inflammatory
17.) Simopoulos AP. Omega-3 fatty acids in inflammation and autoimmune diseases.
J Am Coll Nutr. 2002 Dec;21(6):495-505.
Conclusion: Fish oil more biologically active than ALA; anti-inflammatory
properties; useful in RA and MS among others
18.) Calder PC. Session 3: Joint Nutrition Society and Irish Nutrition and
Dietetic Institute Symposium on 'Nutrition and autoimmune disease' PUFA,
inflammatory processes and rheumatoid arthritis. Proc Nutr Soc. 2008
Nov;67(4):409-18.
Conclusion: fish oil (both EPA and DHA) are anti-inflammatory
19.) Rupp H, Wagner D, Rupp T, Schulte LM, Maisch B. Risk stratification by the
"EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and
antiarrhythmogenic effects of long-chain omega-3 fatty acids. Herz. 2004
Nov;29(7):673-85.
Conclusion: DOSE:2-4 g/day of 84% EPA+DHA ethyl esters for anti-inflammatory
effects
20.) Cleland LG, Caughey GE, James MJ, Proudman SM. Reduction of cardiovascular
risk factors with longterm fish oil treatment in early rheumatoid arthritis.J
Rheumatol. 2006 Oct;33(10):1973-9. Epub 2006 Aug 1.
Conclusion: anti-inflammatory effects of fish oil in RA patients; also reduced
NSAID use with fish oil
21.) Cleland LG, James MJ, Proudman SM. The role of fish oils in the treatment
of rheumatoid arthritis. Drugs. 2003;63(9):845-53.
Conclusion: fish oil anti-inflammatory in RA
22.) Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes RI,
Stocker RP, Parhami N, Greenstein NS, Fuchs BR, et al. Effects of high-dose fish
oil on rheumatoid arthritis after stopping nonsteroidal antiinflammatory drugs.
Clinical and immune correlates. Arthritis
Rheum. 1995 Aug;38(8):1107-14.
Conclusion: Fish oil anti-inflammatory in RA
23.) Pischon T, Hankinson SE, Hotamisligil GS, Rifai N, Willett WC, Rimm EB.
Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory
markers among US men and women. Circulation. 2003 Jul 15;108(2):155-60. Epub
2003 Jun 23.
Conclusion: Fish oil but not ALA associated with decreased inflammatory markers;
Fish oil decreased TNF
24.) Ferrucci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F,
Martin A, Andres-Lacueva C, Senin U, Guralnik JM. Relationship of plasma
polyunsaturated fatty acids to circulating inflammatory markers. J Clin
Endocrinol Metab. 2006 Feb;91(2):439-46. Epub 2005 Oct 18.
Conclusion: Higher EFA's accociated with lower inflammatory markers; n-3 lowers
TNF-alpha and inflammation
25.) Sundrarjun T, Komindr S, Archararit N, Dahlan W, Puchaiwatananon O,
Angthararak S, Udomsuppayakul U, Chuncharunee S. Effects of n-3 fatty acids on
serum interleukin-6, tumour necrosis factor-alpha and soluble tumour necrosis
factor receptor p55 in active rheumatoid
arthritis. J Int Med Res. 2004 Sep-Oct;32(5):443-54.
Conclusion: Fish oil decreaases TNF-alpha, soluble tumour necrosis factor
receptor p55 (sTNF-R p55), CPR and I-6 in RA patients
26.) Yamashita N, Sugiyama E, Hamazaki T, Yano S.Inhibition of natural killer
cell activity by eicosapentaenoic acid in vivo and in vitro.Biochem Biophys Res
Commun. 1988 Jan 15;150(1):497-505.
Conclusion: EPA decreases NK activity
27.) Yamashita N, Yokoyama A, Hamazaki T, Yano S. Inhibition of natural killer
cell activity of human lymphocytes by eicosapentaenoic acid. Biochem Biophys Res
Commun. 1986 Aug 14;138(3):1058-67.
Conclusion: EPA decreases NK activity
28) Yamashita N, Maruyama M, Yamazaki K, Hamazaki T, Yano S. Effect of
eicosapentaenoic and docosahexaenoic acid on natural killer cell activity in
human peripheral blood lymphocytes. Clin Immunol Immunopathol. 1991
Jun;59(3):335-45.
Conclusion: EPA and DHA both inhibit NK cell activity; the effect is greater
(synergistic) when both are used together
29.) Thies F, Nebe-von-Caron G, Powell JR, Yaqoob P, Newsholme EA, Calder PC.
Dietary supplementation with eicosapentaenoic acid, but not with other
long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell
activity in healthy subjects aged >55 y. Am J Clin Nutr. 2001 Mar;73(3):539-48.
Conclusion: NK cell activity was not significantly affected by the placebo, ALA,
GLA, AA, or DHA treatment. Fish oil caused a significant reduction (mean
decline: 48%) in NK cell activity that was fully reversed by 4 wk after
supplementation had ceased. CONCLUSION: A moderate amount of EPA but not of
other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in
healthy subjects." DOSE: 1 g EPA plus DHA (720 mg EPA + 280 mg DHA) daily
30.) James MJ, Ursin VM, Cleland LG. Metabolism of stearidonic acid in human
subjects: comparison with the metabolism of other n-3 fatty acids. Am J Clin
Nutr. 2003 May;77(5):1140-5.
Conclusion: increases of EPA from various sources was 1:0.3:0.07 for EPA:SDA:ALA.
31.) Wallace FA, Miles EA, Calder PC. Comparison of the effects of linseed oil
and different doses of fish oil on mononuclear cell function in healthy human
subjects. Br J Nutr. 2003 May;89(5):679-89.
Conclusion: ALA increases EPA but not DHA; higher dose needed
32.) Arterburn LM, Hall EB, Oken H. Distribution, interconversion, and dose
response of n-3 fatty acids in humans. Am J Clin Nutr. 2006 Jun;83(6 Suppl):1467S-1476S.
Conclusion: ALA not well-converted to EPA and DHA; DOSE: DHA 2 g/day for maximal
tissue response
33.) Young GS, Conquer JA, Thomas R. Effect of randomized supplementation with
high dose olive, flax or fish oil on serum phospholipid fatty acid levels in
adults with attention deficit hyperactivity disorder. Reprod Nutr Dev. 2005
Sep-Oct;45(5):549-58.
Conclusion: fish oil prefferable to flax oil for raising EPA/DHA levels and
decreasing AA/EPA ratios
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