Maxi Flavone™
Broad-Spectrum Herbal Formula
(Anti-inflammatory, Antioxidant and TNF-inhibiting)
Radical
Oxygen Species (ROS), elevated TNF-alpha and
inflammation are known to play a significant role in many cases of
infertility in both men and women.
Radical
Oxygen Species (ROS) and Infertility
Radical Oxygen Species (ROS,
also called "free radicals") include the hydroxyl radical, hydrogen peroxide,
lipid peroxide, hypochlorite, chloramines, superoxide anion, peroxyl radical to
name just a few. Inflammation is a primary cause of increased ROS.
In women, Radical Oxygen Species are detrimental to both natural and
assisted fertility.1-8 ROS is also associated with polycystic ovarian
disease, endometriosis, spontaneous abortions, preeclampsia, hydatidiform mole,
embryopathies, preterm labor, and intrauterine growth retardation.2-3
In men, Radical Oxygen
Species have been shown to decrease sperm motility and concentration and is
associated with male infertility of unknown cause.9-32 ROS in
males also damages DNA and should therefore be corrected even when assisted
pregnancy is planned.31,36,40 The effect of ROS on male
fertility is so well-established that many fertility specialists consider
routinely testing for ROS in sub-fertile men.
Tumor Necrosis Factor-alpha (TNF-α)
and Infertility
Tumor Necrosis Factor-alpha (TNF-a) is an inflammatory cytokine that stimulates
free radical production by mitochondria. Don't let the term "tumor" alarm you;
everyone has TNF-α in their body. Excessive amounts of TNF-α
impair fertility.
In women, high TNF-α
suppresses ovarian function, increases Natural Killer cells (NK cells) and is
associated with infertility. High TNF-α is also
associated with recurrent spontaneous abortion.
In men, high TNF-α is associated with
decreased sperm count and motility.20
Maxi Flavone™
Broad-Spectrum Herbal Formula
Maxi Flavone is a
broad-spectrum herbal antioxidant formula that affords protection from multiple
ROS species, lowers TNF-alpha and is anti-inflammatory. Flavonoid-containing
herbs have a synergistic effect when used in combination.41,71
Maxi Flavone supplies therapeutic doses of the most well-studied
flavonoid herbs including:
I.) Pycnogenol
(Pinus maritima) antioxidant and antiinflammatory effects. Please see the
extensive reference list elsewhere on this website:
Grape Seed Extract and Pycnogenol
II.) Red Grape Seed (Vitus vinifera) with
seeds, skin and stems which therefore contains Resveretrol. Both have
potent antioxidant and anti-inflammatory effects. Please see the extensive
reference list on my website: http://www.drmyattswellnessclub.com/grapeseed.htm
. Resveretrol also suppresses TNF-α.72
Please see the extensive reference list elsewhere on this website:
Grape Seed Extract
III.) Bilberry (Vaccinium myrtillus),
the most potent of the edible berries (39), has significant antioxidant
and anti-inflammatory
properties
41-43,73-7.
Bilberry inhibits TNF-α43 , lipid peroxidation73-74
and is an active radical scavenger of H2O242,76,
superoxide and peroxynitrite.41
IV.) Green Tea
(Camillia sinesis) is an antioxidant
that suppresses
TNF-α.44-48
It has been shown to cause regression of endometriosis in animal models.49-50
V.) Ginkgo (Ginkgo
biloba) is an antioxidant
that has TNF-α
suppressing properties.51-57
Ginkgo raises the radical-scavenging enzymes glutathione, SOD and catalase.51-52
It has also been shown to relieve symptoms of congestive PMS.56
VI.) Milk Thistle (Silybum marianum) is
an antioxidant and antiinflammatory59-63 that significantly inhibits TNF-α.
58-61,63
It has been shown to modulate immune response in vivo.60
VII.) Citrus
Bioflavonoids (with herperidin, narginen and other flavonoids) have
antioxidant64-67,69,
antiinflammatory58,60,64,66,
and TNF-a inhibiting properties.64
Why Dr. Myatt Recommends Maxi Flavone™
Maxi Flavone is a state-of-the-art
formulation of flavonoid-containing herbs with synergistic effects specific to
fertility enhancement. Only full-spectrum extracts, not isolated
flavonoids are included, thus preserving the synergistic activity of all
naturally-occurring phytonutrient compounds.
Maxi Flavone contains optimal doses of the flavonoid herbs which quench
Radical Oxygen Species (ROS), lower TNF-α and NK cell activity (only when
excessive) and decrease excess inflammation.
In addition to the beneficial effect on fertility, these herbs also have
numerous beneficial effects on overall health. Maxi Flavone™ is a potent
formula providing support for immune function, circulatory health, liver
detoxification mechanisms, and antioxidant pathways.
|
Supplement Facts |
|
Serving Size 1 Capsule (60
Caps per bottle) |
|
|
Amount Per
Capsule |
% Daily Value |
|
|
| Pycnogenol®** Pine Bark (Pinus
maritima) dried extract |
5 mg |
* |
|
| Red Grape (Vitis vinifera)
seeds, skin, and stems, dried extract with resveratrol |
100 mg |
* |
|
| Bilberry (Vaccinum
myrtillus) fruit, dried extract, min. 25% anthocyanosides |
60 mg |
* |
|
| Green Tea (Camellia
sinensis) leaf, dried extract, min. 50% catechins (polyphenols) |
180 mg |
* |
|
| Ginkgo (Ginkgo Biloba)
leaf, dried extract, min. 24% ginkgo flavone glycosides and 6%
terpene lactones |
40 mg |
* |
|
| Milk Thistle (Silybum
marianum) fruit, dried extract, min. 80% silymarin |
100 mg |
* |
|
| Citrus Bioflavonoid Complex,
min. 50% bioflavonoids |
125 mg |
* |
|
|
* Daily value not established |
|
Suggested Dose for Fertility:
Women: 1 capsule per day with a meal.
Men: 1 capsule, 2 times per day with meals.
NOTE: Two capsules of Maxi Flavone™ is equivalent to 10 to 12 tablets
or capsules of individual extracts taken separately, resulting in significant
cost savings.
Product #
N308
(60 Caps) $46.95
Enter Quantity Desired and Click "Add To Cart" Button
References 1.) Agarwal A, Allamaneni SS. Role of free radicals in
female reproductive diseases and assisted reproduction. Reprod Biomed Online.
2004 Sep;9(3):338-47.
2.) Agarwal A, Gupta S, Sekhon L, Shah R. Redox considerations in female
reproductive function and assisted reproduction: from molecular mechanisms to
health implications. Antioxid Redox Signal.2008 Aug;10(8):1375-403.
3.) Agarwal A, Gupta S, Sharma RK. Role of oxidative stress in female
reproduction. Reprod Biol Endocrinol. 2005 Jul 14;3:28.
4.) Agarwal A, Gupta S, Sharma R. Oxidative stress and its implications in
female infertility - a clinician's perspective. Reprod Biomed Online. 2005
Nov;11(5):641-50.
5.) Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in
reproduction. Curr Opin Obstet Gynecol. 2006 Jun;18(3):325-32.
6.) Agarwal A, Said TM, Bedaiwy MA, Banerjee J, Alvarez JG. Oxidative stress in
an assisted reproductive techniques setting. Fertil Steril. 2006
Sep;86(3):503-12. Epub 2006 Jul 24.
7.) Agarwal A, Saleh RA, Bedaiwy MA. Role of reactive oxygen species in the
pathophysiology of human reproduction. Fertil Steril. 2003 Apr;79(4):829-43.
8.) Ruder EH, Hartman TJ, Blumberg J, Goldman MB. Oxidative stress and
antioxidants: exposure and impact on female fertility. Hum Reprod Update. 2008
Jul-Aug;14(4):345-57. Epub 2008 Jun 4.9.) Agarwal A, Saleh RA. Role of oxidants
in male infertility: rationale, significance, and treatment. Urol Clin North Am.
2002 Nov;29(4):817-27.
10.) Aitken RJ, Buckingham D, Harkiss D. Use of a xanthine oxidase free radical
generating system to investigate the cytotoxic effects of reactive oxygen
species on human spermatozoa. J Reprod Fertil. 1993 Mar;97(2):441-50.
11.) Armstrong JS, Rajasekaran M, Chamulitrat W, Gatti P, Hellstrom WJ, Sikka
SC. Characterization of reactive oxygen species induced effects on human
spermatozoa movement and energy metabolism. Free Radic Biol Med. 1999
Apr;26(7-8):869-80.
12.) Athayde KS, Cocuzza M, Agarwal A, Krajcir N, Lucon AM, Srougi M, Hallak J.
Development of normal reference values for seminal reactive oxygen species and
their correlation with leukocytes and semen parameters in a fertile population.
J Androl. 2007 Jul-Aug;28(4):613-20. Epub 2007 Apr 4.
13.) Aziz N, Saleh RA, Sharma RK, Lewis-Jones I, Esfandiari N, Thomas AJ Jr,
Agarwal A.Novel association between sperm reactive oxygen species production,
sperm morphological defects, and the sperm deformity index.Fertil Steril. 2004
Feb;81(2):349-54.
14.) Chen Q, Ng V, Mei J, Chia SE. Comparison of seminal vitamin B12, folate,
reactive oxygen species and various sperm parameters between fertile and
infertile males] Wei Sheng Yan Jiu. 2001 Mar;30(2):80-2. [Article in Chinese]
15.) Cocuzza M, Athayde KS, Agarwal A, Sharma R, Pagani R, Lucon AM, Srougi M,
Hallak J.
Age-related increase of reactive oxygen species in neat semen in healthy fertile
men. Urology. 2008 Mar;71(3):490-4.
16.) Cocuzza M, Sikka SC, Athayde KS, Agarwal A. Clinical relevance of oxidative
stress and sperm chromatin damage in male infertility: an evidence based
analysis. Int Braz J Urol. 2007 Sep-Oct;33(5):603-21.
17.) D'Agata R, Vicari E, Moncada ML, Sidoti G, Calogero AE, Fornito MC,
Minacapilli G, Mongioi A, Polosa P. Generation of reactive oxygen species in
subgroups of infertile men. Int J Androl. 1990 Oct;13(5):344-51.
18.) de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa.
Effects on the motility of intact spermatozoa and on sperm axonemes. Impact of
reactive oxygen species on spermatozoa: a balancing act between beneficial and
detrimental effects. Hum Reprod. 1995 Oct;10 Suppl 1:15-21.
19.) de Lamirande E, Gagnon C. Reactive oxygen species and human spermatozoa. I.
Effects on the motility of intact spermatozoa and on sperm axonemes. J Androl.
1992 Sep-Oct;13(5):368-78.
20.) Deepinder F, Cocuzza M, Agarwal A. Should seminal oxidative stress
measurement be offered routinely to men presenting for infertility evaluation?
Endocr Pract. 2008 May-Jun;14(4):484-91.
21.) Ford WC, Whittington K, Williams AC. Reactive oxygen species in human sperm
suspensions: production by leukocytes and the generation of NADPH to protect
sperm against their effects. Int J Androl. 1997;20 Suppl 3:44-9.
22.) Fraczek M, Kurpisz M. Inflammatory mediators exert toxic effects of
oxidative stress on human spermatozoa. J Androl. 2007 Mar-Apr;28(2):325-33. Epub
2006 Nov 1.
23.) Fraczek M, Szumala-Kakol A, Jedrzejczak P, Kamieniczna M, Kurpisz
M.Bacteria trigger oxygen radical release and sperm lipid peroxidation in in
vitro model of semen inflammation. Fertil Steril. 2007 Oct;88(4 Suppl):1076-85.
Epub 2007 Mar 26.
24.) Griveau JF, Le Lannou D. Reactive oxygen species and human spermatozoa:
physiology and pathology. Int J Androl. 1997 Apr;20(2):61-9. 25.) Hammadeh ME,
Radwan M, Al-Hasani S, Micu R, Rosenbaum P, Lorenz M, Schmidt W. Comparison of
reactive oxygen species concentration in seminal plasma and semen parameters in
partners of pregnant and non-pregnant patients after IVF/ICSI. Reprod Biomed
Online. 2006 Nov;13(5):696-706.
26.) Iwasaki A, Gagnon C. Formation of reactive oxygen species in spermatozoa of
infertile patients. Fertil Steril. 1992 Feb;57(2):409-16.
27.) Kefer JC, Agarwal A, Sabanegh E. Role of antioxidants in the treatment of
male infertility. Int J Urol. 2009 Apr 6. [Epub ahead of print]
28.) Novotný J, Oborná I, Brezinová J, Svobodová M, Hrbác J, Fingerová H. The
occurrence of reactive oxygen species in the semen of males from infertile
couples. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2003
Dec;147(2):173-6.
29.) Oborna I, Fingerova H, Novotny J, Brezinova J, Svobodova M, Aziz N.
Reactive oxygen species in human semen in relation to leukocyte contamination.
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):53-7.
30.) Pasqualotto FF, Sharma RK, Pasqualotto EB, Agarwal A. Poor semen quality
and ROS-TAC scores in patients with idiopathic infertility. Urol Int.
2008;81(3):263-70. Epub 2008 Oct 16.
31.) Pasqualotto FF, Sharma RK, Nelson DR, Thomas AJ, Agarwal A. Relationship
between oxidative stress, semen characteristics, and clinical diagnosis in men
undergoing infertility investigation. Fertil Steril. 2000 Mar;73(3):459-64.
32.) Sharma RK, Agarwal A.Role of reactive oxygen species in male
infertility.Urology. 1996 Dec;48(6):835-50.
33.) Sikka SC. Relative impact of oxidative stress on male reproductive
function. Curr Med Chem. 2001 Jun;8(7):851-62.
34.) Smith R, Kaune H, Parodi D, Madariaga M, Morales I, Ríos R, Castro A.
[Extent of sperm DNA damage in spermatozoa from men examined for infertility.
Relationship with oxidative stress] Rev Med Chil. 2007 Mar;135(3):279-86. Epub
2007 Apr 26. [Article in Spanish]
35.) Sheweita SA, Tilmisany AM, Al-Sawaf H. Mechanisms of male infertility: role
of antioxidants. Curr Drug Metab. 2005 Oct;6(5):495-501.
36.) Venkatesh S, Deecaraman M, Kumar R, Shamsi MB, Dada R.Role of reactive
oxygen species in the pathogenesis of mitochondrial DNA (mtDNA) mutations in
male infertility.Indian J Med Res. 2009 Feb;129(2):127-37.
37.) Whittington K, Harrison SC, Williams KM, Day JL, McLaughlin EA, Hull MG,
Ford WC.Reactive oxygen species (ROS) production and the outcome of diagnostic
tests of sperm function. Int J Androl. 1999 Aug;22(4):236-42.
38.) Yumura Y, Iwasaki A, Saito K, Ogawa T, Hirokawa M. Effect of reactive
oxygen species in semen on the pregnancy of infertile couples. Int J Urol. 2009
Feb;16(2):202-7. Epub 2008 Dec 4.
39.) Sharma RK, Pasqualotto FF, Nelson DR, Thomas AJ Jr, Agarwal A. The reactive
oxygen species-total antioxidant capacity score is a new measure of oxidative
stress to predict male infertility. Hum Reprod. 1999 Nov;14(11):2801-7.
40.) Zorn B, Vidmar G, Meden-Vrtovec H. Seminal reactive oxygen species as
predictors of fertilization, embryo quality and pregnancy rates after
conventional in vitro fertilization and intracytoplasmic sperm injection. Int J
Androl. 2003 Oct;26(5):279-85.
41.) Rahman MM, Ichiyanagi T, Komiyama T, Hatano Y, Konishi T. Superoxide
radical- and peroxynitrite-scavenging activity of anthocyanins;
structure-activity relationship and their synergism. Free Radic Res. 2006
Sep;40(9):993-1002.
42.) Yao Y, Vieira A. Protective activities of Vaccinium antioxidants with
potential relevance to mitochondrial dysfunction and neurotoxicity.
Neurotoxicology. 2007 Jan;28(1):93-100. Epub 2006 Jul 31.
43.) Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Anti-angiogenic
property of edible berries. Free Radic Res. 2002 Sep;36(9):1023-31.
44.) Suganuma M, Sueoka E, Sueoka N, Okabe S, Fujiki H. Mechanisms of cancer
prevention by tea polyphenols based on inhibition of TNF-alpha
expression.Biofactors. 2000;13(1-4):67-72.
45.) Fujiki H, Suganuma M, Okabe S, Sueoka E, Suga K, Imai K, Nakachi K. A new
concept of tumor promotion by tumor necrosis factor-alpha, and cancer preventive
agents (-)-epigallocatechin gallate and green tea--a review. Cancer Detect Prev.
2000;24(1):91-9.
46.) Fujiki H, Suganuma M, Kurusu M, Okabe S, Imayoshi Y, Taniguchi S, Yoshida
T.New TNF-alpha releasing inhibitors as cancer preventive agents from
traditional herbal medicine and combination cancer prevention study with EGCG
and sulindac or tamoxifen.Mutat Res. 2003 Feb-Mar;523-524:119-25.
47.) Rietveld A, Wiseman S. Antioxidant effects of tea: evidence from human
clinical trials. J Nutr. 2003 Oct;133(10):3285S-3292S.
48.) Henning SM, Niu Y, Lee NH, Thames GD, Minutti RR, Wang H, Go VL, Heber D.
Bioavailability and antioxidant activity of tea flavanols after consumption of
green tea, black tea, or a green tea extract supplement. Am J Clin Nutr. 2004
Dec;80(6):1558-64.
49.) Xu H, Lui WT, Chu CY, Ng PS, Wang CC, Rogers MS. Anti-angiogenic effects of
green tea catechin on an experimental endometriosis mouse model. Hum Reprod.
2009 Mar;24(3):608-18. Epub 2008 Dec 16.
50.) Laschke MW, Schwender C, Scheuer C, Vollmar B, Menger MD.
Epigallocatechin-3-gallate inhibits estrogen-induced activation of endometrial
cells in vitro and causes regression of endometriotic lesions in vivo. Hum
Reprod. 2008 Oct;23(10):2308-18. Epub 2008 Jul 4.
51.) Feng X, Zhang L, Zhu H. Comparative Anticancer and Antioxidant Activities
of Different Ingredients of Ginkgo biloba Extract (EGb 761). Planta Med. 2009
Mar 13. [Epub ahead of print].
52.) Kaptan ZK, Emir H, Gocmen H, Uzunkulaoglu H, Karakas A, Senes M, Samim E.
Ginkgo biloba, a free oxygen radical scavenger, affects inflammatory mediators
to diminish the occurrence of experimental myringosclerosis. Acta Otolaryngol.
2008 Oct 17:1-6.
53.) Bastianetto S, Zheng WH, Quirion R. The Ginkgo biloba extract (EGb 761)
protects and rescues hippocampal cells against nitric oxide-induced toxicity:
involvement of its flavonoid constituents and protein kinase C.J Neurochem. 2000
Jun;74(6):2268-77.
54.) Nie ZG, Peng SY, Wang WJ. [Effects of ginkgolide B on lipopolysaccharide-induced
TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in
rat pleural polymorphonuclear leukocytes]. Yao Xue Xue Bao. 2004
Jun;39(6):415-8.
55.) Tian YM, Tian HJ, Zhang GY, Dai YR. Effects of Ginkgo biloba extract (EGb
761) on hydroxyl radical-induced thymocyte apoptosis and on age-related thymic
atrophy and peripheral immune dysfunctions in mice. Mech Ageing Dev. 2003
Aug-Sep;124(8-9):977-83.
56.) McKenna DJ, Jones K, Hughes K. Efficacy, safety, and use of ginkgo biloba
in clinical and preclinical applications. Altern Ther Health Med. 2001
Sep-Oct;7(5):70-86, 88-90.
57.) Z'Brun A. [Ginkgo--myth and reality] Praxis (Bern 1994). 1995 Jan
3;84(1):1-6.
58.) Zi X, Mukhtar H, Agarwal R. Novel cancer chemopreventive effects of a
flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous
tumor promoter TNF alpha. Biochem Biophys Res Commun. 1997 Oct 9;239(1):334-9.
59.) Manna SK, Mukhopadhyay A, Van NT, Aggarwal BB. Silymarin suppresses TNF-induced
activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.J Immunol. 1999
Dec 15;163(12):6800-9.
60.) Johnson VJ, He Q, Osuchowski MF, Sharma RP. Physiological responses of a
natural antioxidant flavonoid mixture, silymarin, in BALB/c mice: III. Silymarin
inhibits T-lymphocyte function at low doses but stimulates inflammatory
processes at high doses. Planta Med. 2003 Jan;69(1):44-9.
61.) Polyak SJ, Morishima C, Shuhart MC, Wang CC, Liu Y, Lee DY. Inhibition of
T-cell inflammatory cytokines, hepatocyte NF-kappaB signaling, and HCV infection
by standardized Silymarin. Gastroenterology. 2007 May;132(5):1925-36. Epub 2007
Feb 21.
62.) Feher J, Lang I, Deak G, et al. Free radicals in tissue damage in liver
diseases and therapeutic approach. Tokai J Exp Clin Med 1986;11:121–34.
63.) Toklu HZ, Tunali Akbay T, Velioglu-Ogunc A, Ercan F, Gedik N, Keyer-Uysal
M, Sener G. Silymarin, the antioxidant component of Silybum marianum, prevents
sepsis-induced acute lung and brain injury. J Surg Res. 2008 Apr;145(2):214-22.
Epub 2007 Oct 22.
64.) Matsui T, Ito C, Itoigawa M, Okada T, Furukawa H. Effect of natsudaidain
isolated from Citrus plants on TNF-alpha and cyclooxygenase-2 expression in
RBL-2H3 cells. J Pharm Pharmacol. 2009 Jan;61(1):109-14.
65.) Zielinska-Przyjemska M, Ignatowicz E. Citrus fruit flavonoids influence on
neutrophil apoptosis and oxidative metabolism. Phytother Res. 2008
Dec;22(12):1557-62.
66.) Benavente-García O, Castillo J. Update on uses and properties of citrus
flavonoids: new findings in anticancer, cardiovascular, and anti-inflammatory
activity. J Agric Food Chem. 2008 Aug 13;56(15):6185-205. Epub 2008 Jul 2.
67.) Benavente-García O, Castillo J, Alcaraz M, Vicente V, Del Río JA, Ortuño A.
Beneficial action of Citrus flavonoids on multiple cancer-related biological
pathways. Curr Cancer Drug Targets. 2007 Dec;7(8):795-809.
68.) Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus
flavonoids pertaining to cancer and inflammation. Curr Med Chem. 2001
Feb;8(2):135-53.
69.) Murakami A, Nakamura Y, Ohto Y, Yano M, Koshiba T, Koshimizu K, Tokuda H,
Nishino H, Ohigashi H. Suppressive effects of citrus fruits on free radical
generation and nobiletin, an anti-inflammatory polymethoxyflavonoid. Biofactors.
2000;12(1-4):187-92.
70.) González-Gallego J, Sánchez-Campos S, Tuñón MJ. Anti-inflammatory
properties of dietary flavonoids. Nutr Hosp. 2007 May-Jun;22(3):287-93.
71.) Sagar SM, Yance D, Wong RK. Natural health products that inhibit
angiogenesis: a potential source for investigational new agents to treat
cancer-Part 1. Curr Oncol. 2006 Feb;13(1):14-26.
72.) Manna SK, Mukhopadhyay A,
Aggarwal BB. Resveratrol suppresses TNF-induced activation of nuclear
transcription factors NF-kappa B, activator protein-1, and apoptosis: potential
role of reactive oxygen intermediates and lipid peroxidation. J Immunol. 2000
Jun 15;164(12):6509-19.73.) 35.) Bao L, Yao XS, Tsi D, Yau CC, Chia CS,
Nagai H, Kurihara H.Protective effects of bilberry (Vaccinium myrtillus L.)
extract on KBrO3-induced kidney damage in mice.J Agric Food Chem. 2008 Jan
23;56(2):420-5. Epub 2007 Dec 20.
74.) 36.) Bao L, Yao XS, Yau CC, Tsi D, Chia CS, Nagai H, Kurihara H. Protective
effects of bilberry (Vaccinium myrtillus L.) extract on restraint stress-induced
liver damage in mice. J Agric Food Chem. 2008 Sep 10;56(17):7803-7. Epub 2008
Aug 9.
75.) 37.) Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D.
Berry anthocyanins as novel antioxidants in human health and disease prevention.
Mol Nutr Food Res. 2007 Jun;51(6):675-83.
76.) 38.) Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium
myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi
expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007 May;48(5):2343-9.
77.) 39.) Katsube N, Iwashita K, Tsushida T, Yamaki K, Kobori M. Induction of
apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins.
J Agric Food Chem. 2003 Jan 1;51(1):68-75. |
