DMSA (DiMercapto Succinic Acid)
Oral Chelation for Arsenic, Cadmium, Lead and Mercury
DMSA (meso-2,-3-dimercaptosuccinic acid) is a water soluble sulfhydryl-containing metal chelator that binds to arsenic, cadmium, lead and mercury. It is effective when taken orally and has been used since the 1950's as chelator of heavy metals in the body.
According to Ward Dean, M.D., "Research confirms this substance’s efficacy and safety, and supports its use as the premier oral metal chelator for mercury and its efficacy for other heavy metals. DMSA’s water-solubility, oral dosing, large therapeutic window and low toxicity make it the chelator of choice for many applications."
Although DMSA has a low toxicity, side effects can include rash, nausea or vomiting. Discontinue use of product and consult an holistic physician if these symptoms occur. Do not use during pregnancy or childhood except under the supervision of a physician.
Dr. Myatt's Note: This is the chelator I recommend for use with a 6-hour urine mineral test to detect the presence of heavy metals in the body. When using DMSA on an ongoing basis for oral chelation, please use under the guidance of an holistic physician.
SORRY! Due to FDA regulation his safe and effective supplement is no longer available for sale without a prescription.
The FDA has ruled that it cannot be sold - it seems that there is a prescription drug available that contains the exact same ingredients, so the FDA must "protect" us from the non-prescription supplement form of DMSA.
Your tax dollars, hard at work - "protecting" us all from anything that has not been FDA "approved"! (FDA approval just means that the drug company has paid millions of dollars in licensing and approval fees to the FDA.)
1.) Flora SJ, Bhadauria S, Kannan GM, Singh N. Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.J Environ Biol. 2007 Apr;28(2 Suppl):333-47.
2.) Rooney JP. The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury.Toxicology. 2007 May 20;234(3):145-56. Epub 2007 Mar 1.
3.) Flora SJ, Pande M, Mehta A. Beneficial effect of combined administration of some naturally occurring antioxidants (vitamins) and thiol chelators in the treatment of chronic lead intoxication.Chem Biol Interact. 2003 Jun 15;145(3):267-80.
4.) Flora SJ, Flora G, Saxena G, Mishra M.Arsenic and lead induced free radical generation and their reversibility following chelation.Cell Mol Biol (Noisy-le-grand). 2007 Apr 15;53(1):26-47.
5.) Baum CR.Treatment of mercury intoxication.Curr Opin Pediatr. 1999 Jun;11(3):265-8.
6.) Aposhian HV, Maiorino RM, Rivera M, Bruce DC, Dart RC, Hurlbut KM, Levine DJ, Zheng W, Fernando Q, Carter D, et al. Human studies with the chelating agents, DMPS and DMSA. J Toxicol Clin Toxicol. 1992;30(4):505-28.